Oral administration of polyamines promote adaptation in rodent model of short bowel syndrome
| Project/Area Number |
26461926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 英司 自治医科大学, 医学部, 非常勤講師 (00245044)
佐久間 康成 自治医科大学, 医学部, 准教授 (10296105)
佐田 尚宏 自治医科大学, 医学部, 教授 (20261977)
三木 厚 自治医科大学, 医学部, 講師 (20570378)
安田 是和 自治医科大学, 医学部, 非常勤講師 (40158001)
上本 伸二 京都大学, 医学研究科, 教授 (40252449)
寺谷 工 自治医科大学, 医学部, 講師 (70373404)
藤本 康弘 京都大学, 医学研究科, 特定病院助教 (80335281)
浦橋 泰然 自治医科大学, 医学部, 講師 (90277161)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 短腸症 / ポリアミン / 腸管免疫 / 腸管不全関連肝障害 / 小腸不全関連肝障害 / 脂肪肝 |
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| Outline of Final Research Achievements |
We made short bowel syndrome model rat by resecting of 2/3 small intestine to examine the efficacy of polyamine. In this rodent short bowel syndrome model, polyamine intake orally increase spermidine and spermine in intestine and blood. Additionally, in parallel with the concentration of dietary polyamines, progression of remnant jejunal villous height and IgA elevation in whole blood and feces are confirmed. Furthermore, histological findings revealed dietary polyamines may delay hepatic steatosis which develop as a late complication of short bowel syndrome. It is well known that IgA content in blood and feces correlate positively with gut barrier function. Polyamine intake may
improve survival by activating the function of remnant intestine resulting in independence of parenteral nutrition.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Orthotopic mouse liver transplantation to study liver biology and allograft tolerance.2016
Author(s)
Yokota S, Ueki S, Ono Y, Kasahara N, Pérez-Gutiérrez A, Kimura S, Yoshida O, Murase N, Yasuda Y, Geller D, Thomson A
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Journal Title
Nature Protocols
Volume: XXX
Related Report
Peer Reviewed
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[Journal Article] Oral administration of polyamines ameliorates liver ischemia-reperfusion injury and promotes liver regeneration in rats.2016
Author(s)
Okumura S, Teratani T, Fujimoto Y, Zhao X, Tsuruyama T, Masano Y, Kasahara N, Iida T, Yagi S, Uemura T, Kaido T, Uemoto S.
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Journal Title
Liver Transplantation
Volume: XXX
Issue: 9
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和：短腸症モデルラットを用いたポリアミン摂取による治療効果の検討2015
Author(s)
笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和
Organizer
第101回日本消化器病学会総会
Place of Presentation
仙台市
Year and Date
2015-04-23
Related Report
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