Reactivation of latent cytomegalovirus
| Project/Area Number |
26461928
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
Tanaka Kazuo 昭和大学, 医学部, 教授 (50236569)
|
|---|
| Research Collaborator |
Mori Fumiyo
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | サイトメガロウイルス / 再活性化 / 母乳 / 腸内細菌叢 / 腸内細菌 |
|---|
| Outline of Final Research Achievements |
Cytomegalovirus (CMV) is a typical opportunistic pathogen, and latently infected CMV is reactivated in an immuno-compromized host. Purpose of this study is to make clear the factors concerning reactivation of CMV.
CMV reactivation was noted in breast milk of pregnant and delivered mice latently infected with CMV. This data clearly demonstrated that reactivation of latently infected CMV was non-related to immunosuppression. In addition, such reactivation wad abrogated by treatment of the breast-feeding mice with non-absorbable antibiotics. Thus, indigenous microbiota plays a role in reactivation of CMV. Our results showed that reaction of CMV was caused not by immunosuppression but by alteration of other factors. It is possible that expression levels of such translation factors as NF-κB, CREB and/or AP-1 may participate in reactivation of CMV.
|
Report
(4 results)
Research Products
(10 results)
-
-
-
-
-
[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014
Author(s)
Tomohito Akiyama, Yoichi Miyamoto, Kentaro Yoshimura, Atsushi Yamada, Masamichi Takami, Tetsuo Suzawa, Marie Hoshino, Takahisa Imamura, Chie Akiyama, Rika Yasuhara, Kenji Mishima, Toshifumi Maruyama, Chikara Kohda, Kazuo Tanaka, Jan Potempa, Hisataka Yasuda, Kazuyoshi Baba, Ryutaro Kamijo.
-
Journal Title
J.Biol.Chem.
Volume: 289
Issue: 22
Pages: 1-35
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
