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Reactivation of latent cytomegalovirus

Research Project

Project/Area Number 26461928
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionShowa University

Principal Investigator

Tanaka Kazuo  昭和大学, 医学部, 教授 (50236569)

Research Collaborator Mori Fumiyo  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsサイトメガロウイルス / 再活性化 / 母乳 / 腸内細菌叢 / 腸内細菌
Outline of Final Research Achievements

Cytomegalovirus (CMV) is a typical opportunistic pathogen, and latently infected CMV is reactivated in an immuno-compromized host. Purpose of this study is to make clear the factors concerning reactivation of CMV.
CMV reactivation was noted in breast milk of pregnant and delivered mice latently infected with CMV. This data clearly demonstrated that reactivation of latently infected CMV was non-related to immunosuppression. In addition, such reactivation wad abrogated by treatment of the breast-feeding mice with non-absorbable antibiotics. Thus, indigenous microbiota plays a role in reactivation of CMV. Our results showed that reaction of CMV was caused not by immunosuppression but by alteration of other factors. It is possible that expression levels of such translation factors as NF-κB, CREB and/or AP-1 may participate in reactivation of CMV.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (3 results)

  • [Journal Article] Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung.2016

    • Author(s)
      Ishikawa H, Fukui T, Ino S, Sasaki H, Awano N, Kohda C, and Tanaka K.
    • Journal Title

      Virology

      Volume: 499 Pages: 23-29

    • DOI

      10.1016/j.virol.2016.08.025

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The protective effects of intranasal administration of IL-12 given before influenza virus infection and the negative effects of IL-12 treatment given after viral infection2016

    • Author(s)
      Hiroki Ishikawa, Satoshi Ino, Hiraku Sasaki, Toshie Fukui, Chikara Kohda, and Kazuo Tanaka
    • Journal Title

      J. Med.Virol.

      Volume: 45 Issue: 9 Pages: 210-220

    • DOI

      10.1002/jmv.24494

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral tolerance is inducible during active dextran sulfate sodium-induced colitis2016

    • Author(s)
      Satoshi Ino, Chikara Kohda, Kosuke Takeshima, Hiroki Ishikawa, Tomoko Norose, Toshiko Yamochi, Masafumi Takimoto, Hiroshi Takahashi, Kazuo Tanaka
    • Journal Title

      World J. Gastrointest. Pharmacol. Ther.

      Volume: 7 Issue: 2 Pages: 242-253

    • DOI

      10.4292/wjgpt.v7.i2.242

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A simple smart amplification assay for the rapid detection of human cytomegalovirus in the urine of neonates2014

    • Author(s)
      Kohda C, Chiba N, Shimokoba K, Mizuno K, Negoro T, Nakano Y, Tanaka K
    • Journal Title

      J Virol Methods

      Volume: 208 Pages: 160-165

    • DOI

      10.1016/j.jviromet.2014.07.034

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor and interleukin-1 but suppresses that by interleukin-17: Importance of proteolytic degradation of osteoprotegerin by lysine gingipain.2014

    • Author(s)
      Tomohito Akiyama, Yoichi Miyamoto, Kentaro Yoshimura, Atsushi Yamada, Masamichi Takami, Tetsuo Suzawa, Marie Hoshino, Takahisa Imamura, Chie Akiyama, Rika Yasuhara, Kenji Mishima, Toshifumi Maruyama, Chikara Kohda, Kazuo Tanaka, Jan Potempa, Hisataka Yasuda, Kazuyoshi Baba, Ryutaro Kamijo.
    • Journal Title

      J.Biol.Chem.

      Volume: 289 Issue: 22 Pages: 1-35

    • DOI

      10.1074/jbc.m113.520510

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] インフルエンザウイルス感染に対するIL-12経鼻投与の予防的効果と病態増悪効果2014

    • Author(s)
      石川 裕樹 , 田中 和生
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 62 Pages: 84-89

    • NAID

      40020155480

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] 感染部位に移動したエフェクターT細胞はメモリーT細胞としてリンパ組織で維持される2014

    • Author(s)
      畑 明宏 , 田中 和生 , 戸村 道夫
    • Journal Title

      昭和学士会雑誌

      Volume: 62 Pages: 84-89

    • NAID

      130004692158

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Presentation] サイトメガロウイルスの経母乳感染予防を目的とした電子レンジによる加温法の検討2015

    • Author(s)
      竹島功高、柳川容子、田中和生
    • Organizer
      第63回日本ウイルス学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Presentation] マウスサイトメガロウイルス経母乳感染モデルマウス作成の試み2014

    • Author(s)
      柳川容子・竹島功高・田中和生
    • Organizer
      第62回日本ウイルス学会
    • Place of Presentation
      横浜(横浜国際会議場)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 早産児における母乳を介した症候性サイトメガロウイルス感染症2014

    • Author(s)
      幸田力・千葉奈穂・田中和生
    • Organizer
      第62回日本ウイルス学会
    • Place of Presentation
      横浜(横浜国際会議場)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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