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Continuous hypothermic machine perfusion preservation of pancreas for efficient islet transplantation

Research Project

Project/Area Number 26461933
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionNational Hospital Organization Chiba-East-Hospital

Principal Investigator

Akutsu Naotake  独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 部長 (00344979)

Co-Investigator(Kenkyū-buntansha) 丸山 通広  独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, その他 (40399754)
野口 洋文  琉球大学, 医学(系)研究科(研究院), 教授 (50378733)
大月 和宣  独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (50399755)
西郷 健一  独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (60323424)
松本 育子  独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 部長 (70649128)
青山 博道  独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (80598243)
長谷川 正行  独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, 研究員 (80648030)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords膵島移植 / 持続冷却灌流保存 / 臓器保存 / 膵臓保存 / 持続冷却潅流保存
Outline of Final Research Achievements

Although clinical research of islet transplantation for type 1 diabetes has starts in Japan, severe donor shortage hampers the progress. A possible solution is use of marginal donors such as donors after cardiac death (DCD). A continuous hypothermic perfusion machine, LifePortTM(LP), used for preservation and transportation of marginal kidney for organ transplantation. The effectiveness has been approved especially in the preservation. We applied LP to preservation of pancreas that is sensitive to ischemia reperfusion injury and found that the machine would be efficacious on islet isolation..
In experimental DCD pancreas canine model, continuous hypothermic machine perfusion resulted in higher recovery and function of islets than simple cold storage and two layer method. Further improvement will achieve clinical application of the method on DCD pancreas preservation.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014

All Journal Article (1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 心停止下膵島移植に向けた持続冷却灌流保存法による膵臓保存2017

    • Author(s)
      圷尚武、丸山通広、大月和宣、石田健倫、齋藤友永、西郷健一、長谷川正行、青山博道、剣持敬、野口洋文
    • Journal Title

      Organ Biology

      Volume: 24 Pages: 55-59

    • NAID

      130006035076

    • Related Report
      2017 Annual Research Report
  • [Presentation] Hypothermic machine perfusion preservation of pancreas for islet transplantation in non-heart-beating canine donor model2017

    • Author(s)
      Akutsu N, Ishida T, Maruyama M, Otsuki K, Saitoh T, Saigo K, M, Aoyama H, Kenmochi T, Noguchi H
    • Organizer
      IPITA 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 持続冷却潅流保存による臓器保存2016

    • Author(s)
      圷尚武
    • Organizer
      第43回日本臓器保存生物医学会学術集会
    • Place of Presentation
      八王子
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Hypothermic machine perfusion preservation of non-heart-beating donor pancreas for islet transplantation2016

    • Author(s)
      Naotake Akutsu
    • Organizer
      26th International Congress of the Transplantation Society
    • Place of Presentation
      Hong Kong
    • Year and Date
      2016-08-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心停止下膵島移植のための持続冷却灌流保存法による採取膵保存の検討2016

    • Author(s)
      圷 尚武
    • Organizer
      第43回日本膵・膵島移植研究会
    • Place of Presentation
      広島
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 心停止下膵島分離のための採取膵保存法の検討 シンポジウム(1)「細胞移植の新たな展開」2015

    • Author(s)
      圷 尚武
    • Organizer
      第42回日本臓器保存生物医学会学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 心停止下膵島移植に向けたLifePortによる持続冷却潅流保存の検討2015

    • Author(s)
      圷尚武
    • Organizer
      第42回日本膵・膵島移植研究会
    • Place of Presentation
      新宿
    • Year and Date
      2015-03-06 – 2015-03-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 膵島移植に向けた採取膵持続潅流保存の検討2014

    • Author(s)
      圷尚武
    • Organizer
      第41回日本臓器保存生物医学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-28 – 2014-11-29
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-05-15  

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