Treatment strategy to prevent postoperative recurrence of cancers by inducing host immune responses following neoadjuvant chemotherapy.

• Project/Area Number: 26461935
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Hokkaido University
• Principal Investigator: Tsuchikawa Takahiro 北海道大学, 大学病院, 講師 (50507572)
• Co-Investigator(Kenkyū-buntansha): 平野 聡 北海道大学, 医学研究科, 教授 (50322813) ; 七戸 俊明 北海道大学, 医学研究科, 准教授 (70374353) ; 中村 透 北海道大学, 医学研究科, 助教 (70645796)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 癌 / 腫瘍免疫 / 抗癌剤 / 実験外科学 / 膵癌 / MDSC / GM-CSF / 免疫原性増強 / ＨＬＡ / classI発現増強 / 食道癌術前化学療法 / Immunogenic cell death

Outline of Final Research Achievements

In this research, we investigated the effects of anti-cancer agents and radiotherapy to host immune system in addition to direct cytotoxic effects. Our results showed that the combination between types of cancer and anti-cancer reagents also affect patients prognosis through immune related mechanisms. Based on the results, we published 2 papers.

Research Products

• [Journal Article] Time-dependent transition of the immunoglobulin G subclass and immunoglobulin E response in cancer patients vaccinated with cholesteryl pullulan-melanoma antigen gene-A4 nanogel. (2016)
  • Author(s): Kyogoku N, Ikeda H, Tsuchikawa T, Abiko T, Fujiwara A, Maki T, Yamamura Y, Ichinokawa M, Tanaka K, Imai N, Miyahara Y, Kageyama S, Shiku H, Hirano S.
  • Journal Title: Oncology Letters Volume: 12 Issue: 6 Pages: 4493-4504
  • DOI: 10.3892/ol.2016.5253
  • NAID: 120005981404
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer. (2016)
  • Author(s): Tsuchikawa T, Takeuchi S, Nakamura T, Shichinohe T, Hirano S
  • Journal Title: World Journal of Gastrointestinal Oncology Volume: 8 Pages: 786-792
  • Peer Reviewed / Open Access
• [Journal Article] Stromal Palladin Expression Is an Independent Prognostic Factor in Pancreatic Ductal Adenocarcinoma (2016)
  • Author(s): Sato D, Tsuchikawa T, Mitsuhashi T, Hatanaka Y, Marukawa K, Morooka A, Nakamura T, Shichinohe T, Matsuno Y, Hirano S
  • Journal Title: PLoS One Volume: 11 Issue: 3 Pages: e0152523-e0152523
  • DOI: 10.1371/journal.pone.0152523
  • NAID: 120005757988
  • Peer Reviewed / Open Access
• [Journal Article] Clinical relevance of antigen spreading pattern induced by CHP-MAGE-A4 cancer vaccination (2016)
  • Author(s): Miyauchi K, Tsuchikawa T, Wada M, Abiko T, Kyogoku N, Shichinohe T, Miyahara Y, Kageyama S, Ikeda H, Shiku H, Hirano S.
  • Journal Title: Immunotherapy Volume: 印刷中 Issue: 5 Pages: 527-40
  • DOI: 10.2217/imt-2016-0007
  • Peer Reviewed
• [Journal Article] The key role of calreticulin in immunomodulation induced by chemotherapeutic agents. (2015)
  • Author(s): Yamamura, Tsuchikawa T, Miyauchi K, Takeuchi S, Wada M, Kuwatani T, Kyogoku N, Kuroda A, Maki T, Shichinohe T, Hirano S.
  • Journal Title: Int J Clin Oncol Volume: 20 Issue: 2 Pages: 386-94
  • DOI: 10.1007/s10147-014-0719-x
• [Journal Article] Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human. (2015)
  • Author(s): Takeuchi S, Baghdadi M, Tsuchikawa T, Wada H, Nakamura T, Abe H, Nakanishi S, Usui Y, Higuchi K, Takahashi M, Inoko K, Sato S, Takano H, Shichinohe T, Seino K, Hirano S.
  • Journal Title: Cancer Res Volume: 75 Pages: 2629-40
• [Journal Article] Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: comprehensive immunohistochemical study using a tissue microarray. (2014)
  • Author(s): Nitta T, Mitsuhashi T, Hatanaka Y, Miyamoto M, Oba K, Tsuchikawa T, Suzuki Y, Hatanaka KC, Hirano S, Matsuno Y.
  • Journal Title: Br J Cancer Volume: 111 Issue: 7 Pages: 1363-1372
  • DOI: 10.1038/bjc.2014.415
  • NAID: 120005656331
  • Peer Reviewed / Open Access
• [Presentation] 膵癌局所免疫環境に着目した新規免疫療法の開発 (2016)
  • Author(s): 土川貴裕，武内慎太郎，田中公貴，中西喜嗣，浅野賢道，野路武寛，中村 透，岡村圭祐，七戸俊明，平野 聡
  • Organizer: 第７１回消化器外科学会
  • Place of Presentation: あわぎんホール、アスティ徳島（徳島県徳島市）
  • Year and Date: 2016-07-14
• [Presentation] 膵癌化学療法抵抗性のメカニズム解析とMDSCに着目した新規免疫療法の開発 (2016)
  • Author(s): 土川貴裕，武内慎太郎，中村 透，七戸俊明，平野 聡
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府国際コンベンションセンター（大分県別府市）
  • Year and Date: 2016-05-30
• [Remarks]
  • URL: http://surg2-hokudai.jp/