Study on clinicopathological characteristics and predictive factors for breast cancer with late recurrence

• Project/Area Number: 26461937
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Hokkaido University
• Principal Investigator: Yamashita Hiroko 北海道大学, 大学病院, 教授 (70332947)
• Co-Investigator(Kenkyū-buntansha): 山本 貢 北海道大学, 大学病院, 助教 (20596457) ; 馬場 基 北海道大学, 大学病院, 助教 (90724980) ; 細田 充主 北海道大学, 大学病院, 講師 (40443931)
• Research Collaborator: ISHIDA NAOKO 北海道大学, 北海道大学病院, 医員
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 乳癌 / エストロゲン受容体陽性 / 晩期再発

Outline of Final Research Achievements

We retrospectively collected data from ER-positive, HER2-negative breast cancer patients with early and late distant relapse and patients who remained relapse free for more than 10 years. A total of 223 patients with early distant recurrence and 149 patients with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered. Clinicopathological factors and adjuvant therapies were compared among patients with early and late distant recurrence and patients without recurrence by menopausal status and age. Predictive factors for early and late distant recurrence were identified. Moreover, prognostic factors for post-relapse survival in patients with the early and late recurrence were analyzed.

Research Products

• [Journal Article] Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer (2016)
  • Author(s): Yamashita H, Ogiya A, Shien T, Horimoto Y, Masuda N, Inao T, Osako T, Takahashi M, Endo Y, Hosoda M, Ishida N, Horii R, Yamazaki K, Miyoshi Y, Yasojima H, Tomioka N
  • Journal Title: Breast Cancer Volume: 23 Issue: 6 Pages: 830-843
  • DOI: 10.1007/s12282-015-0649-0
  • NAID: 120006360056
  • Peer Reviewed
• [Journal Article] Post-relapse survival in patients with early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer (2016)
  • Author(s): Ogiya A, Yamazaki K, Horii R, Shien T, Horimoto Y, Masuda N, Inao T, Hosoda M, Ishida N, Osako T, Takahashi M, Endo Y, Miyoshi Y, Yasojima H, Tomioka N, Yamashita H
  • Journal Title: Breast Cancer Volume: - Issue: 3 Pages: 473-482
  • DOI: 10.1007/s12282-016-0730-3
  • NAID: 120006459298
  • Peer Reviewed
• [Journal Article] Differences in expressions of the cancer stem cell marker aldehyde dehydrogenase1 among estrogen receptor-positive/ human epidermal growth factor receptor type 2-negative breast cancer cases with early, late and no recurrence (2016)
  • Author(s): Miyoshi Y, Shien T, Ogiya A, Ishida N, Yamazaki K, Horii R, Horimoto Y, Masuda N, Yasojima H, Inao T, Osako T, Takahashi M, Tomioka N, Endo Y, Hosoda M, Doihara H, Miyoshi S, Yamashita H
  • Journal Title: Breast Cancer Res Volume: 18 Issue: 1 Pages: 73-73
  • DOI: 10.1186/s13058-016-0731-3
  • Peer Reviewed / Open Access
• [Presentation] 晩期再発乳癌の生物学的特徴と予測因子に関する研究 (2015)
  • Author(s): 山下 啓子
  • Organizer: 第23回日本乳癌学会総会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-07-04
• [Presentation] 晩期再発乳癌の生物学的特徴と予測因子に関する研究 (2015)
  • Author(s): 山下啓子
  • Organizer: 第23回日本乳癌学会学術総会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2015-07-02 – 2015-07-04
• [Remarks]
  • URL: http://www2.huhp.hokudai.ac.jp/~breast-w/research_publication.html#publication02
• [Remarks] 北海道大学病院乳腺外科ホームページ
  • URL: http://www2.huhp.hokudai.ac.jp/~breast-w/research_publication.html