| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It was discovered that the expression of aromatase is controlled by RORα, and the ROR response area was identified on the aromatase gene. Further, it was confirmed that proliferative activity of estrogen-sensitive breast cancer cell lines was activated by the aromatase gene. There was a positive correlation between RORα or GR and aromatase expression in breast cancer tissue. Promoter A was significantly higher in ERα-positive breast cancer cell lines and ERα-positive clinical specimens. The correlation between STS and OATP 3A1 was particularly high in the primary tumor of ER-positive breast cancer.
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