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Effects of glucocorticoid receptor on aromatase expression

Research Project

Project/Area Number 26461939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionGunma University

Principal Investigator

Horiguchi Jun  群馬大学, 大学院医学系研究科, 准教授 (70272242)

Co-Investigator(Kenkyū-buntansha) 時庭 英彰  群馬大学, 医学部附属病院, 助教 (50455979)
樋口 徹  群馬大学, 医学部附属病院, 助教 (00526832)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアロマターゼ / RORα / ERα / 乳がん / エストロゲン受容体 / グルココルチコイド受容体 / アロマターゼ / エストロゲン受容体 / グルココルチコイド受容体
Outline of Final Research Achievements

It was discovered that the expression of aromatase is controlled by RORα, and the ROR response area was identified on the aromatase gene. Further, it was confirmed that proliferative activity of estrogen-sensitive breast cancer cell lines was activated by the aromatase gene. There was a positive correlation between RORα or GR and aromatase expression in breast cancer tissue. Promoter A was significantly higher in ERα-positive breast cancer cell lines and ERα-positive clinical specimens. The correlation between STS and OATP 3A1 was particularly high in the primary tumor of ER-positive breast cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015 2014

All Journal Article (16 results) (of which Peer Reviewed: 15 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes2017

    • Author(s)
      Kurozumi S, Yamaguchi Y, Kurosumi M, Ohira M, Matsumoto H, Horiguchi J
    • Journal Title

      J Hum Genet

      Volume: 62(1) Issue: 1 Pages: 15-24

    • DOI

      10.1038/jhg.2016.89

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of immunohistochemical expression of the ubiquitin ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in postmenopausal women with invasive breast cancer2016

    • Author(s)
      Kurozumi S, Yamaguchi Y, Hayashi S, Hiyoshi H, Suda T, Matsumoto H, Takei H, Horiguchi J, Oyama T, Takeyoshi I, Kurosumi M
    • Journal Title

      Cancer Med

      Volume: 5(8) Issue: 8 Pages: 1873-1882

    • DOI

      10.1002/cam4.780

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HER2 intratumoral heterogeneity analyses by concurrent HER2 gene and protein assessment for the prognosis of HER2 negative invasive breast cancer patients2016

    • Author(s)
      Kurozumi S, Padilla M, Kurosumi M, Matsumoto H, Inoue K, Horiguchi J, Takeyoshi I, Oyama T, Ranger-Moore J, Allred DC, Dennis E, Nitta H
    • Journal Title

      Breast Cancer Res Treat

      Volume: 158(1) Issue: 1 Pages: 99-111

    • DOI

      10.1007/s10549-016-3856-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of estrone sulfate to cell proliferation in aromatase inhibitor-resistant, hormone receptor-positive breast cancer2016

    • Author(s)
      Higuchi T, Endo M, Hanamura T, Gohno T, Niwa T, Yamaguchi Y, Horiguchi J, Takeyoshi I, Hayashi S
    • Journal Title

      PLOS ONE

      Volume: 11(5) Issue: 5 Pages: e0155844-e0155844

    • DOI

      10.1371/journal.pone.0155844

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of aromatase and estrogen receptor beta expression in EGFR wild-type lung adenocarcinoma2016

    • Author(s)
      Tanaka K, Shimizu K, Kakegawa S, Ohtaki Y, Nagashima T, Kaira K, Horiguchi J, Oyama T, Takeyoshi I
    • Journal Title

      Am J Transl Res

      Volume: 8(1) Pages: 81-97

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers2016

    • Author(s)
      Tsuboi M, Yamane A, Horiguchi J, Yokobori T, Kawabata-Iwakawa R, Yoshiyama S, Rokudai S, Odawara H, Tokiniwa H, Oyama T, Takeyoshi I, Nishiyama M
    • Journal Title

      Breast Cancer

      Volume: 23(5) Issue: 5 Pages: 780-8

    • DOI

      10.1007/s12282-015-0641-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 乳癌術前化学療法におけるCTC検査の意義2016

    • Author(s)
      堀口 淳
    • Journal Title

      細胞

      Volume: 48(5) Pages: 17-20

    • Related Report
      2016 Annual Research Report
  • [Journal Article] ER陽性原発性乳癌におけるOrganic Anion Transporter Peptides(OATP)と臨床病理学的因子との関連性について2015

    • Author(s)
      内田 紗弥香、樋口 徹、堀口 淳、他
    • Journal Title

      乳癌基礎研究

      Volume: 23 Pages: 39-42

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Randomized Controlled Trial of Zoledronic Acid plus Chemotherapy versus Chemotherapy Alone as Neoadjuvant Treatment of HER2-Negative Primary Breast Cancer (JONIE Study)2015

    • Author(s)
      Hasegawa Y, Tanino H, Horiguchi J, et al.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 12 Pages: e0143643-e0143643

    • DOI

      10.1371/journal.pone.0143643

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers2015

    • Author(s)
      Tsuboi M, Yamane A, Horiguchi J, et al.
    • Journal Title

      Breast Cancer

      Volume: なし

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ER, PgR, Ki67, p27(Kip1), and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab2015

    • Author(s)
      Kurozumi S, Inoue K, Horiguchi J, et al.
    • Journal Title

      BMC Cancer

      Volume: なし Issue: 1

    • DOI

      10.1186/s12885-015-1641-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible Cardiomyopathy After Epirubicin Administration2015

    • Author(s)
      Koitabashi N, Ohyama Y, Horiguchi J, et al.
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 4 Pages: 466-468

    • DOI

      10.1536/ihj.14-416

    • NAID

      130005087576

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Everolimus Plus Exemestane in Postmenopausal Patients with Estrogen-Receptor-Positive Advanced Breast Cancer - Japanese Subgroup Analysis of BOLERO -22015

    • Author(s)
      Ito Y, Masuda N, Iwata H, Mukai H, Horiguchi J, Tokuda Y, Kuroi K, Mori A, Ohno N, Noguchi S
    • Journal Title

      Gan To Kagaku Ryoho

      Volume: 42 Pages: 67-75

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protein expression, gene amplification, and mutational analysis of EGFR in triple-negative breast cancer2014

    • Author(s)
      Nakajima H, Ishikawa Y, Furuya M, Sano T, Ohno Y, Horiguchi J, Oyama T
    • Journal Title

      Breast Cancer

      Volume: 21 Pages: 66-74

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Variation in Use of Estrogen Receptor-α Gene Promoters in Breast Cancer Compared by Quantification of Promoter-Specific Messenger RNA2014

    • Author(s)
      Higuchi T, Gohno T, Nagatomo T, Tokiniwa H, Niwa T, Horiguchi J, Oyama T, Takeyoshi I, Hayashi SI
    • Journal Title

      Clin Breast Cancer

      Volume: 14 Pages: 249-257

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 乳癌術後に高カルシウム血症を契機に発見された悪性リンパ腫の1例2014

    • Author(s)
      吉田 崇、木村盛彦、後藤與四成、堀口 淳、竹吉 泉
    • Journal Title

      Kitakanto Med J

      Volume: 64 Pages: 159-163

    • NAID

      130004775550

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Prognostic factors in patients with operable breast cancer who received neoadjuvant chemotherapy2016

    • Author(s)
      Horiguchi J
    • Organizer
      European Breast Cancer Conference 10
    • Place of Presentation
      アムステルダム
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 根治性と整容性の両立を目指した乳頭温存乳房切除術と一次二期乳房再建2015

    • Author(s)
      堀口 淳、牧口貴哉、高他大輔、長岡りん、佐藤亜矢子、時庭英彰、内田紗弥香、樋口 徹、坪井美樹、菊地麻美、竹吉 泉
    • Organizer
      第115回日本外科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-16 – 2015-04-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Circulating tumor cells before neoadjuvant chemotherapy in operable breast cancer2015

    • Author(s)
      Jun Horiguchi, Daisuke Takata, Nana Rokutanda, Rin Nagaoka, Ayako Sato, Hideaki Tokiniwa, Toru Higuchi, Sayaka Uchida, Miki Tsuboi, Mami Kikuchi, Izumi Takeyoshi
    • Organizer
      14th St. Gallen International Breast Cancer Conference
    • Place of Presentation
      ウィーン
    • Year and Date
      2015-03-18 – 2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 乳癌脳転移のサブタイプ別の治療法と予後2014

    • Author(s)
      堀口 淳、高他大輔、六反田奈和、長岡りん、佐藤亜矢子、時庭英彰、内田紗弥香、荻野美里、樋口 徹、菊地麻美、竹尾 健、狩野貴之、竹吉 泉
    • Organizer
      第22回日本乳癌学会学術総会 シンポジウム15「脳転移」
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-10 – 2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 根治手術可能原発性乳癌におけるcirculating tumor cellsの意義と術前化学療法による変化2014

    • Author(s)
      堀口 淳、高他大輔、六反田奈和、長岡りん、佐藤亜矢子、時庭英彰、内田紗弥香、荻野美里、菊地麻美、竹吉 泉
    • Organizer
      日本外科学会 ワークショップ
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Book] 乳がんにおけるTILs(tumor-infiltrating lymphocytes)の意義2016

    • Author(s)
      黒住 献、堀口 淳、松本広志、黒住昌史
    • Total Pages
      8
    • Publisher
      メビオ
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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