Effects of glucocorticoid receptor on aromatase expression
| Project/Area Number |
26461939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Gunma University |
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Principal Investigator |
Horiguchi Jun 群馬大学, 大学院医学系研究科, 准教授 (70272242)
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| Co-Investigator(Kenkyū-buntansha) |
時庭 英彰 群馬大学, 医学部附属病院, 助教 (50455979)
樋口 徹 群馬大学, 医学部附属病院, 助教 (00526832)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アロマターゼ / RORα / ERα / 乳がん / エストロゲン受容体 / グルココルチコイド受容体 / ｱﾛﾏﾀｰｾﾞ / ｴｽﾄﾛｹﾞﾝ受容体 / ｸﾞﾙｺｺﾙﾁｺｲﾄﾞ受容体 |
|---|
| Outline of Final Research Achievements |
It was discovered that the expression of aromatase is controlled by RORα, and the ROR response area was identified on the aromatase gene. Further, it was confirmed that proliferative activity of estrogen-sensitive breast cancer cell lines was activated by the aromatase gene. There was a positive correlation between RORα or GR and aromatase expression in breast cancer tissue. Promoter A was significantly higher in ERα-positive breast cancer cell lines and ERα-positive clinical specimens. The correlation between STS and OATP 3A1 was particularly high in the primary tumor of ER-positive breast cancer.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Prognostic significance of immunohistochemical expression of the ubiquitin ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in postmenopausal women with invasive breast cancer2016
Author(s)
Kurozumi S, Yamaguchi Y, Hayashi S, Hiyoshi H, Suda T, Matsumoto H, Takei H, Horiguchi J, Oyama T, Takeyoshi I, Kurosumi M
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Journal Title
Cancer Med
Volume: 5(8)
Issue: 8
Pages: 1873-1882
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] HER2 intratumoral heterogeneity analyses by concurrent HER2 gene and protein assessment for the prognosis of HER2 negative invasive breast cancer patients2016
Author(s)
Kurozumi S, Padilla M, Kurosumi M, Matsumoto H, Inoue K, Horiguchi J, Takeyoshi I, Oyama T, Ranger-Moore J, Allred DC, Dennis E, Nitta H
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Journal Title
Breast Cancer Res Treat
Volume: 158(1)
Issue: 1
Pages: 99-111
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers2016
Author(s)
Tsuboi M, Yamane A, Horiguchi J, Yokobori T, Kawabata-Iwakawa R, Yoshiyama S, Rokudai S, Odawara H, Tokiniwa H, Oyama T, Takeyoshi I, Nishiyama M
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Journal Title
Breast Cancer
Volume: 23(5)
Issue: 5
Pages: 780-8
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Circulating tumor cells before neoadjuvant chemotherapy in operable breast cancer2015
Author(s)
Jun Horiguchi, Daisuke Takata, Nana Rokutanda, Rin Nagaoka, Ayako Sato, Hideaki Tokiniwa, Toru Higuchi, Sayaka Uchida, Miki Tsuboi, Mami Kikuchi, Izumi Takeyoshi
Organizer
14th St. Gallen International Breast Cancer Conference
Place of Presentation
ウィーン
Year and Date
2015-03-18 – 2015-03-21
Related Report
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