| Project/Area Number |
26461940
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三階 貴史 千葉大学, 医学部附属病院, 助教 (00375685)
長嶋 健 千葉大学, 医学部附属病院, 准教授 (60292710)
藤本 浩司 埼玉医科大学, 医学部, 講師 (60456027)
宮崎 勝 国際医療福祉大学, 大学病院, 教授 (70166156)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞外マトリックス / 治療抵抗性 / ニッチ / 化学療法抵抗性 / テネイシンC |
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| Outline of Final Research Achievements |
Nine extra cellular matrix (ECM) were evaluated as a relative factor of resistance to chemotherapy. Incease of tenascin C and fibronectin were significantly correlated to resistance of chemotherapy. In patients with ALDH1-positive cell, tenascin C and fibronection were correlated to resistance of chemotherapy. Double positive of tenascin C and fibronection showed more correlation to chemo-resistance than that of single positive of tenascin C. In IHC analysis, assembly of ALDH1-positive cancer cells in invasive head lesion and Tenascin C-positive stromal tissue was confirmed. Furthermore, in stromal tissue just closed to invasive head, assembly of tenascin C and fibronection was confirmed.
These data suggest that tenascin C connects to fibronection in stromal tissue just closed to invasive head, forms complex, combines to ALDH1-positive cancer cells as niche and correlated to chemo-resistance. We hope a new therapy targeting to niche to decrease chemo-resistance.
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