| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
It has been reported that myeloid-derived suppressor cells (MDSC) are associated with long-term survival and tolerance in transplantation. We demonstrated that monocytic MDSCs are successfully induced from peripheral blood monocytes with our established method and these MDSCs significantly suppressed the xenogeneic rejection by NK cells, cytotoxic T cells and macrophages(Xenotransplantation 2014:21:46-56,Transpl Immunol 2015:33:140-5).
Moreover, we examined the suppression of xenogeneic rejection in gene-modified porcine endothelial cells. Our findings indicate that MDSC has has a potential to induce more powerful tolerance against xenogeneic rejection in combination with generation of gene modified pigs.
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