MDSC-induced suppression of xenogeneic rejection in combination with gene-modification in porcine endotherial cells
| Project/Area Number |
26461944
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
Maeda Akira 大阪大学, 医学系研究科, 招へい研究員 (00319708)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAGAWA Shuji 大阪大学, 医学系研究科, 准教授 (90273648)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MDSC / 異種移植 / 拒絶反応 / トレランス / マイロファージ / 細胞障害活性 / マクロファージ |
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| Outline of Final Research Achievements |
It has been reported that myeloid-derived suppressor cells (MDSC) are associated with long-term survival and tolerance in transplantation. We demonstrated that monocytic MDSCs are successfully induced from peripheral blood monocytes with our established method and these MDSCs significantly suppressed the xenogeneic rejection by NK cells, cytotoxic T cells and macrophages(Xenotransplantation 2014:21:46-56,Transpl Immunol 2015:33:140-5).
Moreover, we examined the suppression of xenogeneic rejection in gene-modified porcine endothelial cells. Our findings indicate that MDSC has has a potential to induce more powerful tolerance against xenogeneic rejection in combination with generation of gene modified pigs.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] HLA-G1, but not HLA-G3, suppresses human monocyte/macrophage-mediated swine endothelial cell lysis.2016
Author(s)
Eguchi H, Maeda A, Lo PC, Matsuura R, Esquivel EL, Asada M, Sakai R, Deguchi K, Ueno T, Okuyama H, Miyagawa S
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Journal Title
Tranplant proceedings
Volume: 48
Pages: 1285-1287
Related Report
Peer Reviewed
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[Journal Article] Human HLA-Ev (147) Expression in Transgenic Animals.2016
Author(s)
Akira Maeda, Thuy-vy Choi, Pei-Chi Lo, Rieko Sakai, Mayumi Asada, Kazuaki Yamanaka, Kengo Nakahata, Rei Matsuura, Hiroshi Eguchi, Hiroomi Okuyama, Shuji Miyagawa
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Journal Title
Tranplant proceedings
Volume: 48
Pages: 1323-1325
Related Report
Peer Reviewed
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[Journal Article] Expression of a Synthetic Gene of CTDM by Transgenic Animals.2016
Author(s)
Sakai R, Maeda A, Matsuura R, Eguchi H, Lo P, Hasuwa H, Ikawa M, Nakahata K, Zenitani M, Yamamichi T, Umeda S, Okuyama H, Miyagawa S.
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Journal Title
Tranplant proceedings
Volume: 48
Pages: 1279-1281
Related Report
Peer Reviewed
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[Journal Article] Monocytic MDSCs regulate macrophage-mediated xenogenic cytotoxicity.2015
Author(s)
Maeda A,Eguchi H,Nakahata K,LO PC,Yamanaka K,Kawamura T,Matsuura R,Sakai R,Asada M,Okuyama H,Miyagawa s
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Journal Title
Transpl Immunol
Volume: 33
Pages: 140-145
Related Report
Peer Reviewed
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