New strategy for hypothyroidism with use of regenerative medicine.
| Project/Area Number |
26461950
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
MINAMI Shigeki 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (90398165)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
崎村 千香 長崎大学, 病院(医学系), 助教 (00567175)
山之内 孝彰 長崎大学, 医歯薬学総合研究科(医学系), 講師 (10448508)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 甲状腺細胞シート / 再生医療 / 甲状腺 / 細胞シート |
|---|
| Outline of Final Research Achievements |
1. We successfully fabricated cell sheets with using thyroid cell of resected human thyroid tissues. 2. These cell sheets expressed thyroid cell-specific markers, i. e., TTF1、TG. Furthermore, cultured thyroid cells produced and secreted thyroid hormone in culture medium. 3. Multilayer thyroid cell sheets with fibroblasts (human TIG118) did not show increase in thyroid hormone production compared to monolayer thyroid cell sheets.
|
Report
(5 results)
Research Products
(1 results)
