Clinical significance and molecular mechanism elucidation of E-cadherin expression in triple-negative breast cancer
Project/Area Number |
26461957
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Osaka City University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
川尻 成美 大阪市立大学, 大学院医学研究科, 登録医 (40597283)
大平 雅一 大阪市立大学, 大学院医学研究科, 教授 (90203926)
高島 勉 大阪市立大学, 大学院医学研究科, 講師 (80336776)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | トリプルネガティブ乳癌 / 個別化治療 / 上皮間葉転換 / E-cadherin |
Outline of Final Research Achievements |
Triple-negative breast cancer (TNBC), a subtype of breast cancer that is estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and human epidermal growth factor receptor 2 (HER2)-negative, has a poor prognosis. Recent research indicates that TNBC can be categorized into seven specific subcategories based on genetic expression profiles. In this study, we showed the possibility of a new therapeutic strategy for TNBC.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Expression and clinical significance of androgen receptor in triple-negative breast cancer.2017
Author(s)
Asano Y, Kashiwagi S, Goto W, Takada K, Tanaka S, Morisaki T, Takashima T, Noda S, Onoda N, Ohsawa M, Hirakawa K, Ohira M.
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Journal Title
Cancers
Volume: 9
Issue: 1
Pages: 4-4
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A case of multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis.2017
Author(s)
Sera T, Kashiwagi S, Takashima T, Asano Y, Goto W, Iimori N, Noda S, Onoda N, Ohsawa M, Hirakawa K, Ohira M.
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Journal Title
BMC Res Notes
Volume: 10
Issue: 1
Pages: 55-55
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Use of tumor-infiltrating lymphocytes (TILs) to predict the treatment response to eribulin chemotherapy in breast cancer.2017
Author(s)
Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Noda S, Takashima T, Onoda N, Tomita S, Ohsawa M, Hirakawa K, Ohira M.
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Journal Title
PLoS ONE
Volume: 12
Issue: 2
Pages: e0170634-e0170634
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Nonfunctional adrenocortical carcinoma initially presenting as retroperitoneal haemorrhage.2015
Author(s)
Kashiwagi S, Amano R, Onoda N, Noda S, Hirata K, Asano Y, Kurata K, Miura K, Yamazoe S, Kimura K, Ohsawa M, Kitagawa S, Hirakawa K.
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Journal Title
BMC Surgery
Volume: 15
Issue: 1
Pages: 46-46
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 24.Strategy of operative treatment of hyperparathyroidism using US scan and 99mTc-MIBI SPECT/CT.2014
Author(s)
Noda S, Onoda N, Kashiwagi S, Kawajiri H, Takashima T, Ishikawa T, Yoshida A, Higashiyama S, Kawabe J, Imanishi Y, Tahara H, Inaba M, Osawa M, Hirakawa K.
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Journal Title
Endcrine J
Volume: 61
Pages: 225-230
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Predicting therapeutic effect by on tumor-infiltrating lymphocytes (TILs) in endocrine therapy for stage IV breast cancer2016
Author(s)
Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Koji Takada, Tsutomu Takashima, Tamami Morisaki, Satoru Noda, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
Organizer
San Antonio Breast Cancer Symposium (SABCS)
Place of Presentation
San Antonio, Texas, USA
Year and Date
2016-12-06
Related Report
Int'l Joint Research
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[Presentation] Prediction of The Treatment Response to Docetaxel, Trastuzumab and Pertuzumab Combination Regimen Chemotherapy in Breast Cancer using TILs2016
Author(s)
Shinichiro Kashiwagi, Tsutomu Takashima, Yuka Asano, Wataru Goto, Koji Takada, Tamami Morisaki, Satoru Noda, Naoyoshi Onoda, Kosei Hirakawa, Masaichi Ohira
Organizer
4th Federation of Asian Clinical Oncology (FACO)
Place of Presentation
Amoi, China
Year and Date
2016-09-22
Related Report
Int'l Joint Research
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[Presentation] Prediction of the treatment response to eribulin chemotherapy in breast cancer using tumor-infiltrating lymphocytes (TILs)2016
Author(s)
Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Kento Kurata, Tamami Morisaki, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Sayaka Tanaka, Masahiko Ohsawa, Masaichi Ohira, Kosei Hirakawa
Organizer
American Association for Cancer Research (AACR)
Place of Presentation
New Orleans, Louisiana, USA
Year and Date
2016-04-16
Related Report
Int'l Joint Research
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