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Clinical significance and molecular mechanism elucidation of E-cadherin expression in triple-negative breast cancer

Research Project

Project/Area Number 26461957
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionOsaka City University

Principal Investigator

Kashiwagi Shinichiro  大阪市立大学, 大学院医学研究科, 講師 (80637017)

Co-Investigator(Kenkyū-buntansha) 川尻 成美  大阪市立大学, 大学院医学研究科, 登録医 (40597283)
大平 雅一  大阪市立大学, 大学院医学研究科, 教授 (90203926)
高島 勉  大阪市立大学, 大学院医学研究科, 講師 (80336776)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsトリプルネガティブ乳癌 / 個別化治療 / 上皮間葉転換 / E-cadherin
Outline of Final Research Achievements

Triple-negative breast cancer (TNBC), a subtype of breast cancer that is estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and human epidermal growth factor receptor 2 (HER2)-negative, has a poor prognosis. Recent research indicates that TNBC can be categorized into seven specific subcategories based on genetic expression profiles. In this study, we showed the possibility of a new therapeutic strategy for TNBC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (27 results)

All 2017 2016 2015 2014 Other

All Journal Article (19 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 19 results,  Open Access: 19 results,  Acknowledgement Compliant: 18 results) Presentation (7 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Journal Article] Expression and clinical significance of androgen receptor in triple-negative breast cancer.2017

    • Author(s)
      Asano Y, Kashiwagi S, Goto W, Takada K, Tanaka S, Morisaki T, Takashima T, Noda S, Onoda N, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      Cancers

      Volume: 9 Issue: 1 Pages: 4-4

    • DOI

      10.3390/cancers9010004

    • NAID

      130005161483

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A case of multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis.2017

    • Author(s)
      Sera T, Kashiwagi S, Takashima T, Asano Y, Goto W, Iimori N, Noda S, Onoda N, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      BMC Res Notes

      Volume: 10 Issue: 1 Pages: 55-55

    • DOI

      10.1186/s13104-017-2375-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Use of tumor-infiltrating lymphocytes (TILs) to predict the treatment response to eribulin chemotherapy in breast cancer.2017

    • Author(s)
      Kashiwagi S, Asano Y, Goto W, Takada K, Takahashi K, Noda S, Takashima T, Onoda N, Tomita S, Ohsawa M, Hirakawa K, Ohira M.
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 2 Pages: e0170634-e0170634

    • DOI

      10.1371/journal.pone.0170634

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Tumour-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to neoadjuvant chemotherapy of aggressive breast cancer.2016

    • Author(s)
      Asano Y, Kashiwagi S, Goto W, Kurata K, Noda S, Takashima T, Onoda N, Tanaka S, Ohsawa M, Hirakawa K.
    • Journal Title

      Br J Surg

      Volume: 103 Issue: 7 Pages: 845-854

    • DOI

      10.1002/bjs.10127

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical verification of sensitivity to preoperative chemotherapy in cases of androgen receptor-expressing positive breast cancer.2016

    • Author(s)
      Asano Y, Kashiwagi S, Onoda N, Kurata K, Morisaki T, Noda S, Takashima T, Ohsawa M, Kitagawa S, Hirakawa K.
    • Journal Title

      Br J Cancer

      Volume: 12 Issue: 1 Pages: 14-20

    • DOI

      10.1038/bjc.2015.434

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Predictive Value of Neutrophil/Lymphocyte Ratio for Efficacy of Preoperative Chemotherapy in Triple-Negative Breast Cancer.2016

    • Author(s)
      Asano Y, Kashiwagi S, Onoda N, Noda S, Kawajiri H, Takashima T, Ohsawa M, Kitagawa S, Hirakawa K.
    • Journal Title

      Ann Surg Oncol

      Volume: 23 Issue: 4 Pages: 1104-1110

    • DOI

      10.1245/s10434-015-4934-0

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Platelet lymphocyte ratio as a useful predictor of the therapeutic effect of neoadjuvant chemotherapy in breast cancer.2016

    • Author(s)
      Asano Y, Kashiwagi S, Onoda N, Noda S, Kawajiri H, Takashima T, Ohsawa M, Kitagawa S, Hirakawa K.
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 7 Pages: e0153459-e0153459

    • DOI

      10.1371/journal.pone.0153459

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Platelet lymphocyte ratio as a useful predictor of the therapeutic effect of neoadjuvant chemotherapy in breast cancer2016

    • Author(s)
      Yuka Asano, Shinichiro Kashiwagi, Naoyoshi Onoda, Satoru Noda, Hidemi Kawajiri, Tsutomu Takashima, Masahiko Ohsawa, Seiichi Kitagawa, Kosei Hirakawa
    • Journal Title

      PLOS ONE

      Volume: 5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Partial mastectomy using manual blunt dissection (MBD) in early breast cancer.2015

    • Author(s)
      Kashiwagi S, Onoda N, Asano Y, Kurata K, Morisaki T, Noda S, Kawajiri H, Takashima T, Hirakawa K.
    • Journal Title

      BMC Surg.

      Volume: 15 Issue: 1 Pages: 117-117

    • DOI

      10.1186/s12893-015-0102-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ambulatory sentinel lymph node biopsy preceding neoadjuvant therapy in patients with operable breast cancer: a preliminary study.2015

    • Author(s)
      Kashiwagi S, Onoda N, Asano Y, Kurata K, Noda S, Kawajiri H, Takashima T, Ohsawa M, Kitagawa S, Hirakawa K.
    • Journal Title

      World J Surg Oncol

      Volume: 13 Issue: 1 Pages: 53-53

    • DOI

      10.1186/s12957-015-0471-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nonfunctional adrenocortical carcinoma initially presenting as retroperitoneal haemorrhage.2015

    • Author(s)
      Kashiwagi S, Amano R, Onoda N, Noda S, Hirata K, Asano Y, Kurata K, Miura K, Yamazoe S, Kimura K, Ohsawa M, Kitagawa S, Hirakawa K.
    • Journal Title

      BMC Surgery

      Volume: 15 Issue: 1 Pages: 46-46

    • DOI

      10.1186/s12893-015-0031-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer.2015

    • Author(s)
      Kawajiri H, Takashima T, Kashiwagi S, Noda S, Onoda N, Hirakawa K.
    • Journal Title

      Expert Rev Anticancer Ther.

      Volume: 15 Issue: 1 Pages: 17-26

    • DOI

      10.1586/14737140.2015.992418

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] T-stage and positive sentinel nodes ratio are the useful factors to predict non-sentinel node metastasis in breast cancer patients with macro-metastasis in the sentinel node.2015

    • Author(s)
      Noda S, Onoda N, Asano Y, Kurata K, Kashiwagi S, Kawajiri H, Takashima T, Hirakawa K.
    • Journal Title

      Int J Surg

      Volume: 14 Pages: 56-60

    • DOI

      10.1016/j.ijsu.2015.01.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A rare recurrence of bilateral breast cancer in the esophagus coincidentally associated with primary gastric cancer: a case report.2014

    • Author(s)
      Kashiwagi S, Onoda N, Asano Y, Noda S, Kawajiri H, Takashima T, Ishikawa T, Hirakawa K.
    • Journal Title

      J Med Case Rep

      Volume: 8 Issue: 1 Pages: 58-58

    • DOI

      10.1186/1752-1947-8-58

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 24.Strategy of operative treatment of hyperparathyroidism using US scan and 99mTc-MIBI SPECT/CT.2014

    • Author(s)
      Noda S, Onoda N, Kashiwagi S, Kawajiri H, Takashima T, Ishikawa T, Yoshida A, Higashiyama S, Kawabe J, Imanishi Y, Tahara H, Inaba M, Osawa M, Hirakawa K.
    • Journal Title

      Endcrine J

      Volume: 61 Pages: 225-230

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Establishment, characterization and comparison of seven authentic anaplastic thyroid cancer cell lines retaining clinical features of the original tumors.2014

    • Author(s)
      Onoda N, Nakamura M, Aomatsu N, Noda S, Kashiwagi S, Hirakawa K.
    • Journal Title

      World J Surg

      Volume: 38 Issue: 3 Pages: 688-695

    • DOI

      10.1007/s00268-013-2409-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 21.Prognostic significance of pathological complete response following neoadjuvant chemotherapy for operable breast cancer.2014

    • Author(s)
      Kawajiri H, Takashima T, Aomatsu N, Kashiwagi S, Noda S, Onoda N, Ishikawa T, Hirakawa K.
    • Journal Title

      Oncology Letters

      Volume: 7 Pages: 663-668

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 20.E-cadherin expression and cell proliferation in the primary tumor and metastatic lymph nodes of papillary thyroid mirocarcinoma.2014

    • Author(s)
      Nakamura M, Onoda N, Noda S, Kashiwagi S, Aomatsu N, Kurata K, Kawajiri H, Takashima T, Ishikawa T, Hirakawa K.
    • Journal Title

      Mol Clin Oncol

      Volume: 2 Pages: 226-232

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 19.Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline.2014

    • Author(s)
      Aomatsu N, Yashiro M, Kashiwagi S, Kawajiri H, Takashima T, Ohsawa M, Wakasa K, Hirakawa K.
    • Journal Title

      BMC Cancer

      Volume: 14 Issue: 1 Pages: 400-400

    • DOI

      10.1186/1471-2407-14-400

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Predicting therapeutic effect by on tumor-infiltrating lymphocytes (TILs) in endocrine therapy for stage IV breast cancer2016

    • Author(s)
      Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Koji Takada, Tsutomu Takashima, Tamami Morisaki, Satoru Noda, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
    • Organizer
      San Antonio Breast Cancer Symposium (SABCS)
    • Place of Presentation
      San Antonio, Texas, USA
    • Year and Date
      2016-12-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of The Treatment Response to Docetaxel, Trastuzumab and Pertuzumab Combination Regimen Chemotherapy in Breast Cancer using TILs2016

    • Author(s)
      Shinichiro Kashiwagi, Tsutomu Takashima, Yuka Asano, Wataru Goto, Koji Takada, Tamami Morisaki, Satoru Noda, Naoyoshi Onoda, Kosei Hirakawa, Masaichi Ohira
    • Organizer
      4th Federation of Asian Clinical Oncology (FACO)
    • Place of Presentation
      Amoi, China
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prediction of the treatment response to eribulin chemotherapy in breast cancer using tumor-infiltrating lymphocytes (TILs)2016

    • Author(s)
      Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Kento Kurata, Tamami Morisaki, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Sayaka Tanaka, Masahiko Ohsawa, Masaichi Ohira, Kosei Hirakawa
    • Organizer
      American Association for Cancer Research (AACR)
    • Place of Presentation
      New Orleans, Louisiana, USA
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Kashiwagi S, Asano Y, Morisaki T, Noda S, Kawajiri H, Takashima T, Onoda N, Hirakawa K.2015

    • Author(s)
      Epithelial-mesenchymal transition and tumor vascular remodeling in eribulin chemotherapy for breast cancer
    • Organizer
      American Association for Cancer Research 2015
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Predictive Value of Neutrophil-Lymphocyte Ratio for the Efficacy of Preoperative Chemotherapy in Triple-negative Breast Cancer2015

    • Author(s)
      Asano Y, Kashiwagi S, Morisaki T, Noda S, Kawajiri H, Takashima T, Onoda N, Hirakawa K.
    • Organizer
      American Association for Cancer Research 2015
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 15.TLE3 is a useful marker for predicting the therapeutic effect of eribulin chemotherapy for triple-negative breast cance.2014

    • Author(s)
      Kashiwagi S, Asano Y, Kurata K, Morisaki T, Noda S, Kawajiri H, Takashima T, Onoda N, Maeda K, Hirakawa K.
    • Organizer
      39th European Society for Medical Oncology
    • Place of Presentation
      Madrid (Spain)
    • Year and Date
      2014-09-26 – 2014-09-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 16.Expression and clinical significance of androgen receptor in triple-negative breast cancer.2014

    • Author(s)
      Asano Y, Kashiwagi S, Kurata K, Morisaki T, Noda S, Kawajiri H, Takashima T, Onoda N, Maeda K, Hirakawa K.
    • Organizer
      39th European Society for Medical Oncology
    • Place of Presentation
      Madrid (Spain)
    • Year and Date
      2014-09-26 – 2014-09-30
    • Related Report
      2014 Research-status Report
  • [Remarks] 大阪市立大学大学院医学研究科腫瘍外科学講座

    • URL

      http://www.med.osaka-cu.ac.jp/departments/zouki-g-surgical-oncology.shtml

    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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