HOXB9 expression in breast cancer predicts efficacy of bevacizumab treatment
Project/Area Number |
26461959
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General surgery
|
Research Institution | Keio University |
Principal Investigator |
Tetsu Hayashida 慶應義塾大学, 医学部(信濃町), 講師 (80327543)
|
Co-Investigator(Kenkyū-buntansha) |
神野 浩光 帝京大学, 医学部, 教授 (20216261)
高橋 麻衣子 慶應義塾大学, 医学部(信濃町), 助教 (50348661)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 乳癌 / ベバシズマブ / 血管新生 / HOXB9 / 乳がん |
Outline of Final Research Achievements |
Homeobox B9 (HOXB9), a transcriptional factor, regulates developmental processes and tumor progression and has recently been recognized as a strong angiogenic factor in breast cancer progresson. This study aimed to investigate the role of HOXB9 in tumorigenesis and angiogenesis. Bevacizumab, an anti-VEGF antibody, remarkably suppressed tumor proliferation by inhibiting angiogenesis in HOXB9-overexpressing xenografts. HOXB9 promotes the secretion of angiogenic factors, including VEGF, to induce tumor proliferation through microenvironmental communication via IL6 signaling; moreover, silencing of VEGF or IL6 terminates microenvironmental crosstalk. Thus, HOXB9 and IL6 may be surrogate markers for bevacizumab treatment in breast cancer.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Bevacizumab terminates homeobox B9-induced tumor proliferation by silencing microenvironmental communication.2014
Author(s)
Yoshinori Hoshino, Tetsu Hayashida, Akira Hirata, Hidena Takahashi, Naokazu Chiba, Mitsuyo Ohmura, Masatoshi Wakui, Hiromitsu Jinno, Hirotoshi Hasegawa, Shyamala Maheswaran, Makoto Suematsu, Yuko Kitagawa,
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Journal Title
Molecular Cancer
Volume: 13(1)
Issue: 1
Pages: 102-102
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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