Functional analysis of tumor suppressor gene BAP1, NPM1 complex
| Project/Area Number |
26461962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 癌抑制遺伝子 / DNA修復 / 脱ユビキチン化 |
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| Outline of Final Research Achievements |
As a result of research, the following was found out.
NPM 1 binds to BAP 1 in the region of 1 - 122
BAP１, NPM 1 complex controls HCF 1 pathway, controls chromatin remodeling and involved in apoptosis induction.
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Report
(5 results)
Research Products
(4 results)
