Action mechanisms responsible for the development of resistance to endocrine therapy in breast cancer and overcoming the resistance: focusing on a role of breast cancer stem cells
| Project/Area Number |
26461964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森谷 卓也 川崎医科大学, 医学部, 教授 (00230160)
鹿股 直樹 川崎医科大学, 医学部, 准教授 (60263373)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 乳癌 / 癌幹細胞 / エストロゲン / ヘッジホッグシグナル / 内分泌療法抵抗性 / GANT61 / 抗エストロゲン薬 / 細胞増殖抑制 / GLI / Hedgehogシグナル / Gli1 |
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| Outline of Final Research Achievements |
Most breast cancers are estrogen-dependent and sensitive to endocrine therapy. However, resistance to endocrine therapy occurs and makes endocrine therapy ineffective. We focused on a role of breast cancer stem cells in the development of the resistance. Regulatory mechanisms of estrogen on breast cancer stem cells were investigated in vitro. We found that estrogen regulates breast cancer stem cells through estrogen receptor and hedgehog signaling pathway.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Clinicopathological characteristics of breast cancer and trends in the management of breast cancer patients in Japan: Based on the Breast Cancer Registry of the Japanese Breast Cancer Society between 2004 and 2011.2015
Author(s)
Kurebayashi J, Miyoshi Y, Ishikawa T, Saji S, Sugie T, Suzuki T, Takahashi S, Nozaki M, Yamashita H, Tokuda Y, Nakamura S
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Journal Title
Breast Cancer
Volume: 22
Issue: 3
Pages: 235-244
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model.2015
Author(s)
Duquette M, Sadow PM, Fischer A, Song C, Husain A, Rizaldos EC, Makrogiorgos M, Kurebayashi J, Nose V, Van Hummelen P, Bronson RT, Dias-Santagata D, Pandolfi PP, Nucera C
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Journal Title
Oncotarget
Volume: 6
Issue: 40
Pages: 42445-42467
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The cell cycle profiling-risk score based on CDK1 and 2 predicts early recurrence in node-negative, hormone receptor-positive breast cancer treated with endocrine therapy.2014
Author(s)
Kim SJ, Masuda N, Tsukamoto F, Inaji H, Akiyama F, Sonoo H, Kurebayashi J, Yoshidome K, Tsujimoto M, Takei H, Masuda S, Nakamura S, Noguchi S.
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Journal Title
Cancer Lett.
Volume: 355
Issue: 2
Pages: 217-223
DOI
Related Report
Peer Reviewed / Open Access
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