Analysis of gene expression involved in the prognosis and occurrence site of gastrointestinal stromal tumors

• Project/Area Number: 26461970
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: ISHIKAWA Takashi 新潟大学, 医歯学総合病院, 准教授 (70586940)
• Co-Investigator(Kenkyū-buntansha): 若井 俊文 新潟大学, 医歯学系, 教授 (50372470) ; 羽入 隆晃 新潟大学, 医歯学総合病院, 助教 (50719705) ; 小杉 伸一 新潟大学, 医歯学総合病院, 特任教授 (90401736) ; 小山 諭 新潟大学, 医歯学系, 教授 (10323966) ; 亀山 仁史 新潟大学, 医歯学系, 准教授 (40626420) ; 市川 寛 新潟大学, 医歯学系, 助教 (50721875)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 消化管間質腫瘍

Outline of Final Research Achievements

Gastrointestinal stromal tumor (GIST) of the small intestine has poor prognosis compared to that of the stomach. We focused on the involvement of the DNPH1 gene, which is known to be involved in autonomous cell proliferation and tumorigenesis. We confirmed that GISTs of the small intestine had high malignant potential clinically and examined the expression of DNPH1 using surgically resected specimens. DNPH1 expression were clearly observed in GIST specimens both of the small intestine and of the stomach. Although differences of the DNPH1 expression due to differences in primary organs was not clear, the expression of DNPH1 may contributes to tumor involvement.

Research Products

• [Journal Article] Prognostic factors after imatinib secondary resistance: survival analysis in patients with unresectable and metastatic gastrointestinal stromal tumors. (2016)
  • Author(s): Kanda T, Ishikawa T, Kosugi S-I, Ueki K, Naito T, Wakai T, Hirota S.
  • Journal Title: Int J Clin Oncol. Volume: 21 Issue: 2 Pages: 295-301
  • DOI: 10.1007/s10147-015-0903-7
  • Peer Reviewed
• [Journal Article] Surgical resection of recurrent gastrointestinal stromal tumor after interruption of long-term nilotinib therapy. (2016)
  • Author(s): Sugase T, Takahashi T, Ishikawa T, Ichikawa H, Kanda T, Hirota S, Nakajima K, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Takiguchi S, Wakai T, Mori M, Doki Y.
  • Journal Title: Surg Case Rep. Volume: 2 Issue: 1 Pages: 137-137
  • DOI: 10.1186/s40792-016-0266-y
  • Peer Reviewed
• [Presentation] Gastrointestinal stromal tumor followed without treatment - a report of three cases. (2017)
  • Author(s): 石川卓
  • Organizer: 第89回日本胃癌学会総会
  • Place of Presentation: 広島国際会議場（広島県広島市）
• [Presentation] 高齢者消化管間質腫瘍に対するイマチニブ治療 (2016)
  • Author(s): 石川卓
  • Organizer: 第80回 日本胃癌学会総会
  • Place of Presentation: B-Con Plaza 別府国際コンベンションセンター（大分県・別府市）
  • Year and Date: 2016-03-17
• [Presentation] 初発消化管間質腫瘍の手術成績 (2015)
  • Author(s): 石川卓
  • Organizer: 第115回 日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-16 – 2015-04-18
• [Presentation] 初発消化管間質腫瘍の手術成績 (2015)
  • Author(s): 石川卓
  • Organizer: 第115回 日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-04-16