| Project/Area Number |
26461970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
若井 俊文 新潟大学, 医歯学系, 教授 (50372470)
羽入 隆晃 新潟大学, 医歯学総合病院, 助教 (50719705)
小杉 伸一 新潟大学, 医歯学総合病院, 特任教授 (90401736)
小山 諭 新潟大学, 医歯学系, 教授 (10323966)
亀山 仁史 新潟大学, 医歯学系, 准教授 (40626420)
市川 寛 新潟大学, 医歯学系, 助教 (50721875)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 消化管間質腫瘍 |
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| Outline of Final Research Achievements |
Gastrointestinal stromal tumor (GIST) of the small intestine has poor prognosis compared to that of the stomach. We focused on the involvement of the DNPH1 gene, which is known to be involved in autonomous cell proliferation and tumorigenesis. We confirmed that GISTs of the small intestine had high malignant potential clinically and examined the expression of DNPH1 using surgically resected specimens. DNPH1 expression were clearly observed in GIST specimens both of the small intestine and of the stomach. Although differences of the DNPH1 expression due to differences in primary organs was not clear, the expression of DNPH1 may contributes to tumor involvement.
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