Development of biomarkers for precision medicine in early gastric cancer
| Project/Area Number | 26461973 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
円谷 彰 横浜市立大学, 附属市民総合医療センター, 准教授 (00236936) [Withdrawn]
大島 貴 横浜市立大学, 医学部, 准教授 (10448665)
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| Research Collaborator |
SAKAMOTO JUNICHI
TANAKA SHIRO
MIYAGI YOHEI
TAN Patrick
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed(Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost : ¥3,700,000、Indirect Cost : ¥1,110,000)
Fiscal Year 2016 : ¥1,560,000 (Direct Cost : ¥1,200,000、Indirect Cost : ¥360,000)
Fiscal Year 2015 : ¥1,690,000 (Direct Cost : ¥1,300,000、Indirect Cost : ¥390,000)
Fiscal Year 2014 : ¥1,560,000 (Direct Cost : ¥1,200,000、Indirect Cost : ¥360,000)
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| Keywords | 胃癌 / 5FU / タキサン / 予後因子 / 効果予測因子 / OPRT / TS / NT / TK / 耐性 / 胃癌補助化学療法 / 胃癌個別化療法 / バイオマーカー |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the prognostic and predictive factor for gastric cancer using the samples of the patients enrolled in the SAMIT trial, which investigating the efficacy of the postoperative chemotherapy for gastric cancer. Ohshima et al. extracted RNA from the samples and performed the pattern analysis of mRNA expression and the quantitative RT-PCR for 101 genes. Yoshida et al. analyzed the mechanism of the resistance to 5FU using gastric cancer cell lines, and found that the reduction of F-deoxyuridine monophosphate by nucleotidase was one of the mechanism for the resistance to 5FU in gastric cancer.
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Report
(4results)
Research Products
(20results)
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[Journal Article] Adjuvant capecitabine plus oxaliplatin after D2 gastrectomy in Japanese patients with gastric cancer: a phase II study2017
Author(s)
Fuse N, Bando H, Chin K, Ito S, Yoshikawa T, Tsuburaya A, Terashima M, Kawashima Y, Fukunaga T, Gotoh M, Emi Y, Yoshida K, Oki E, Takahashi S, Kuriki H, Sato K, Sasako M
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Journal Title
Gastric Cancer
Volume : 20
Pages : 332-340
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinicopathological factors associated with HER2 status in gastric cancer: results from a prospective multicenter observational cohort study in a Japanese population (JFMC44-1101)2016
Author(s)
Matsusaka S, Nashinmoto A, Nishikawa K, Miki A, Miwa H, Yamaguchi K, Yoshikawa T, Ochiai A, Morita S, Sano T, Kodera Y, Kakeji Y, Sakamoto J, Saji S, Yoshida K
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Journal Title
Gastric Cancer
Volume : 19
Pages : 839-851
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Significant Role of Cyclin D1 in the Synergistic Growth-inhibitory Effect of Combined Therapy of Vandetanib with 5-Fluorouracil for Gastric Cancer2016
Author(s)
Yawata K, Osada S, Tanahashi T, Matsui S, Sasaki Y, Tanaka Y, Okumura N, Matsuhashi N, Takahashi T, Yamaguchi K, Yoshida K
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Journal Title
Anticancer Research
Volume : 36
Pages : 5215-5226
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase 3 factorial randomised controlled trial2014
Author(s)
Tsuburaya A, Yoshida K, Kobayashi M, Yoshino S, Takahashi M, Takiguchi N, Tanabe K,Takahashi N, Imamura H, Tatsumoto N, Hara H, Nishikawa K, Fukushima R, Nozaki I, Kojima H, Miyashita Y, Oba K, Buyse M, Morita M, Sakamoto J
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Journal Title
Lancet Oncology
Volume : 15
Pages : 886-893
DOI
Related Report
Peer Reviewed / Open Access
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