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Identification of biomarker for peritoneal dissemination from gastric cancer: analysis of lnc RNA

Research Project

Project/Area Number 26461975
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionMie University

Principal Investigator

Mohri Yasuhiko  三重大学, 医学系研究科, 准教授 (70345974)

Co-Investigator(Kenkyū-buntansha) 問山 裕二  三重大学, 医学部附属病院, 講師 (00422824)
田中 光司  三重大学, 医学系研究科, 客員准教授 (10345986)
楠 正人  三重大学, 医学系研究科, 教授 (50192026)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords胃癌 / 腹膜播種 / バイオマーカー / lnc RNA / long non-coding RNA / 網羅的解析
Outline of Final Research Achievements

The prognosis of gastric cancer (GC) patients with peritoneal dissemination remains poor, and a better understanding of the underlying mechanisms is critical for the development of new treatments that will improve survival in these patients. This study aimed to clarify the clinical and biological role of two key metastasis-associated long non-coding RNAs (lncRNAs) in GC. We analyzed the expression levels of two lncRNAs in gastric tissues. Expression of 2 lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients.Our data provide novel evidence for the biological and clinical significance of HOTAIR expression as a potential biomarker for identifying patients with peritoneal metastasis, and as a novel therapeutic target in patients with gastric neoplasia.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (6 results)

  • [Journal Article] Circulating micro RNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer2016

    • Author(s)
      Hiroki Imaoka, Yuji Toiyama, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Masaki Ohi, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri
    • Journal Title

      Gastric Cancer

      Volume: 19 Issue: 3 Pages: 744-753

    • DOI

      10.1007/s10120-015-0521-0

    • NAID

      40020881612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients.2015

    • Author(s)
      Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.
    • Journal Title

      Carcinogenesis

      Volume: 36 Pages: 1474-1483

    • DOI

      10.1093/carcin/bgv139

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preoperative prediction of peritoneal metastasis in gastric cancer as an indicator for neoadjuvant treatment.2015

    • Author(s)
      Ohi M, Mori K, Toiyama Y, Mohri Y, Okigami M, Yasuda H, Saigusa S, Tanaka K, Inoue Y, Kusunoki M.
    • Journal Title

      Anticancer Res

      Volume: 35 Pages: 3511-3518

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of RacGAP1 expression at the invasive front of gastric cancer.2015

    • Author(s)
      Saigusa S, Tanaka K, Mohri Y, Ohi M, Shimura T, Kitajima T, Kondo S, Okugawa Y, Toiyama Y, Inoue Y, Kusunoki M.
    • Journal Title

      Gastric Cancer

      Volume: 18 Issue: 1 Pages: 84-92

    • DOI

      10.1007/s10120-014-0355-1

    • NAID

      40020580250

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of prognostic factors and surgical indications for metastatic gastric cancer.2014

    • Author(s)
      Mohri Y, Tanaka K, Ohi M, Saigusa S, Yasuda H, Toiyama Y, Araki T, Inoue Y, Kusunoki M.
    • Journal Title

      BMC Cancer

      Volume: 14 Issue: 1 Pages: 409-409

    • DOI

      10.1186/1471-2407-14-409

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis.2014

    • Author(s)
      Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, Goel A.
    • Journal Title

      Carcinogenesis

      Volume: 35 Issue: 12 Pages: 2731-2739

    • DOI

      10.1093/carcin/bgu200

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of tartrate-resistant acid phosphatase type-5 expression in human gastric cancer.2014

    • Author(s)
      Kawamura M, Tanaka K, Toiyama Y, Okugawa Y, Okigami M, Yasuda H, Saigusa S, Ohi M, Inoue Y, Uchida K, Mohri Y, Kusunoki M.
    • Journal Title

      Anticancer Res

      Volume: 34 Pages: 3425-3429

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 胃癌腹膜播種の基礎と臨床 新たなエビデンスの創出に向けて 転移関連lncRNAの胃癌腹膜播種進展における臨床病理・機能的意義2016

    • Author(s)
      奥川喜永、, 問山 裕二, 三枝 晋, 川村 幹雄, 大井 正貴, 田中 光司, 井上 靖浩, 毛利 靖彦, 三木 誓雄, 楠 正人
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール(徳島県・徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inflammation-nutritional indexからみた高齢者胃癌根治手術2015

    • Author(s)
      毛利 靖彦, 田中 光司, 大井 正貴, 安田 裕美, 沖上 正人, 野口 智史, 荒木 俊光, 井上 靖浩, 楠 正人
    • Organizer
      第77回日本臨床外科学会総会
    • Place of Presentation
      福岡国際会議場(福岡県・博多市)
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 胃癌切除後の予後におけるBMI(Body Mass Index)の影響2015

    • Author(s)
      安田 裕美, 問山 裕二, 野口 智史, 沖上 正人, 大井 正貴, 田中 光司, 毛利 靖彦, 荒木 俊光, 井上 靖浩, 楠 正人
    • Organizer
      第77回日本臨床外科学会総会
    • Place of Presentation
      福岡国際会議場(福岡県・博多市)
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 二光子レーザー顕微鏡を用いたマウス胃癌腹膜播種モデルにおける生体内可視化とpaclitaxel腹腔内投与後の癌細胞の形態学的変化の継時的観察2014

    • Author(s)
      志村 匡信, 田中 光司, 井出 正造, 小池 勇樹, 沖上 正人, 今岡 裕基, 北嶋 貴仁, 近藤 哲, 奥川 喜永, 三枝 晋, 問山 裕二, 大井 正貴, 荒木 俊光, 井上 靖浩, 内田 恵一, 毛利 靖彦, 溝口 明, 楠 正人
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院における腹膜播種胃癌および洗浄細胞診陽性胃癌に対する検討2014

    • Author(s)
      沖上 正人, 大井 正貴, 志村 匡信, 安田 裕美, 三枝 晋, 問山 裕二, 荒木 俊光, 田中 光司, 井上 靖浩, 内田 恵一, 毛利 靖彦, 楠 正人
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌腹膜転移巣における抗MET抗体の二光子励起顕微鏡下生体内可視化2014

    • Author(s)
      井出 正造, 田中 光司, 志村 匡信, 今岡 裕基, 近藤 哲, 北嶋 貴仁, 三枝 晋, 問山 裕二, 大井 正貴, 安田 裕美, 沖上 正人, 奥川 喜永, 井上 靖浩, 荒木 俊光, 毛利 靖彦, 楠 正人
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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