Identification of biomarker for peritoneal dissemination from gastric cancer: analysis of lnc RNA
Project/Area Number |
26461975
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Mie University |
Principal Investigator |
Mohri Yasuhiko 三重大学, 医学系研究科, 准教授 (70345974)
|
Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 講師 (00422824)
田中 光司 三重大学, 医学系研究科, 客員准教授 (10345986)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 胃癌 / 腹膜播種 / バイオマーカー / lnc RNA / long non-coding RNA / 網羅的解析 |
Outline of Final Research Achievements |
The prognosis of gastric cancer (GC) patients with peritoneal dissemination remains poor, and a better understanding of the underlying mechanisms is critical for the development of new treatments that will improve survival in these patients. This study aimed to clarify the clinical and biological role of two key metastasis-associated long non-coding RNAs (lncRNAs) in GC. We analyzed the expression levels of two lncRNAs in gastric tissues. Expression of 2 lncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these lncRNAs significantly correlated with peritoneal metastasis in GC patients.Our data provide novel evidence for the biological and clinical significance of HOTAIR expression as a potential biomarker for identifying patients with peritoneal metastasis, and as a novel therapeutic target in patients with gastric neoplasia.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Circulating micro RNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer2016
Author(s)
Hiroki Imaoka, Yuji Toiyama, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Masaki Ohi, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri
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Journal Title
Gastric Cancer
Volume: 19
Issue: 3
Pages: 744-753
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients.2015
Author(s)
Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.
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Journal Title
Carcinogenesis
Volume: 36
Pages: 1474-1483
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Clinical significance of RacGAP1 expression at the invasive front of gastric cancer.2015
Author(s)
Saigusa S, Tanaka K, Mohri Y, Ohi M, Shimura T, Kitajima T, Kondo S, Okugawa Y, Toiyama Y, Inoue Y, Kusunoki M.
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Journal Title
Gastric Cancer
Volume: 18
Issue: 1
Pages: 84-92
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis.2014
Author(s)
Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, Goel A.
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Journal Title
Carcinogenesis
Volume: 35
Issue: 12
Pages: 2731-2739
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of tartrate-resistant acid phosphatase type-5 expression in human gastric cancer.2014
Author(s)
Kawamura M, Tanaka K, Toiyama Y, Okugawa Y, Okigami M, Yasuda H, Saigusa S, Ohi M, Inoue Y, Uchida K, Mohri Y, Kusunoki M.
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Journal Title
Anticancer Res
Volume: 34
Pages: 3425-3429
Related Report
Peer Reviewed
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[Presentation] 二光子レーザー顕微鏡を用いたマウス胃癌腹膜播種モデルにおける生体内可視化とpaclitaxel腹腔内投与後の癌細胞の形態学的変化の継時的観察2014
Author(s)
志村 匡信, 田中 光司, 井出 正造, 小池 勇樹, 沖上 正人, 今岡 裕基, 北嶋 貴仁, 近藤 哲, 奥川 喜永, 三枝 晋, 問山 裕二, 大井 正貴, 荒木 俊光, 井上 靖浩, 内田 恵一, 毛利 靖彦, 溝口 明, 楠 正人
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都国際会館
Year and Date
2014-04-03 – 2014-04-05
Related Report
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[Presentation] 当院における腹膜播種胃癌および洗浄細胞診陽性胃癌に対する検討2014
Author(s)
沖上 正人, 大井 正貴, 志村 匡信, 安田 裕美, 三枝 晋, 問山 裕二, 荒木 俊光, 田中 光司, 井上 靖浩, 内田 恵一, 毛利 靖彦, 楠 正人
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都国際会館
Year and Date
2014-04-03 – 2014-04-05
Related Report
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[Presentation] 胃癌腹膜転移巣における抗MET抗体の二光子励起顕微鏡下生体内可視化2014
Author(s)
井出 正造, 田中 光司, 志村 匡信, 今岡 裕基, 近藤 哲, 北嶋 貴仁, 三枝 晋, 問山 裕二, 大井 正貴, 安田 裕美, 沖上 正人, 奥川 喜永, 井上 靖浩, 荒木 俊光, 毛利 靖彦, 楠 正人
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都国際会館
Year and Date
2014-04-03 – 2014-04-05
Related Report