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Comprehensive analysis and treatment strategy of MicroRNA that regulates peritoneal metastasis of gastric cancer

Research Project

Project/Area Number 26461976
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionMie University

Principal Investigator

Okigami Masato  三重大学, 医学系研究科, リサーチアソシエイト (90722596)

Co-Investigator(Kenkyū-buntansha) 問山 裕二  三重大学, 医学部附属病院, 講師 (00422824)
楠 正人  三重大学, 医学系研究科, 教授 (50192026)
毛利 靖彦  三重大学, 医学系研究科, 准教授 (70345974)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords胃癌 / microRNA / 腹膜播種 / 遠隔転移 / micro RNA / 血清 / 予後マーカー / micro RNA
Outline of Final Research Achievements

Comprehensive microRNA (miRNA) analysis was analyzed for expression of microRNAs from gastric cancer tumor tissue and normal tissue. MiRNAs involved in epithelial mesenchymal transition correlated with distant metastasis of gastric cancer. Serum miR-203 was identified and it was shown that it was significantly lower in stage IV gastric cancer patients than in stage I - III gastric cancer patients, and this low expression was found to be an independent predictive marker of poor prognosis in gastric cancer patients.
The fact that MTA-1 expression in gastric cancer tissues is useful as a peritoneal dissemination predictor, and that the high expression of gastric cancer tissue ANGPTL 2 and the increase in ANGPTL 2 concentration in serum correlate with peritoneal dissemination and are useful for differentiation of poor prognosis group Indicated.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Metastasis-associated protein is a predictive biomarker for metastasis and recurrence in gastric cancer.2016

    • Author(s)
      Okugawa Y, Mohri Y, Tanaka K, Kawamura M, Saigusa S, Toiyama Y, Ohi M, Inoue Y, Miki C, Kusunoki M.
    • Journal Title

      Oncology Report

      Volume: 36(4) Issue: 4 Pages: 1893-1900

    • DOI

      10.3892/or.2016.5054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating micro RNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer2016

    • Author(s)
      Hiroki Imaoka, Yuji Toiyama, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Masaki Ohi, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri
    • Journal Title

      Gastric Cancer

      Volume: 19 Issue: 3 Pages: 744-753

    • DOI

      10.1007/s10120-015-0521-0

    • NAID

      40020881612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer.2015

    • Author(s)
      Imaoka H1, Toiyama Y, Okigami M, Yasuda H, Saigusa S, Ohi M, Tanaka K, Inoue Y, Mohri Y, Kusunoki M.
    • Journal Title

      gastric cancer

      Volume: 2015

    • NAID

      40020881612

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MicroRNA-503 promotes tumor progression and acts as a novel biomarker for prognosis in oesophageal cancer.2015

    • Author(s)
      Ide S, Toiyama Y, Shimura T, Kawamura M, Yasuda H, Saigusa S, Ohi M, Tanaka K, Mohri Y, Kusunoki M.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1447-1451

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis.2014

    • Author(s)
      Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, Goel A.
    • Journal Title

      Carcinogenesis

      Volume: 35 Issue: 12 Pages: 2731-2739

    • DOI

      10.1093/carcin/bgu200

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 胃癌腹膜播種の基礎と臨床 新たなエビデンスの創出に向けて 転移関連lncRNAの胃癌腹膜播種進展における臨床病理・機能的意義2016

    • Author(s)
      奥川 喜永, 問山 裕二, 三枝 晋, 川村 幹雄, 大井 正貴, 田中 光司, 井上 靖浩, 毛利 靖彦, 三木 誓雄, 楠 正人
    • Organizer
      日本消化器外科学会総会 71回
    • Place of Presentation
      アスティ徳島(徳島県、徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Circulating microRNA-203 Predicts Metastases, Early Recurrence, and Poor Prognosis in Human Gastric Cancer2015

    • Author(s)
      Yuji Toiyama, Hiroki Imaoka, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Masaki Ohi, Minako Kobayashi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki
    • Organizer
      DDW 2015
    • Place of Presentation
      Washington, DC(アメリカ)
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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