Comprehensive analysis and treatment strategy of MicroRNA that regulates peritoneal metastasis of gastric cancer
Project/Area Number |
26461976
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Mie University |
Principal Investigator |
Okigami Masato 三重大学, 医学系研究科, リサーチアソシエイト (90722596)
|
Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 講師 (00422824)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
毛利 靖彦 三重大学, 医学系研究科, 准教授 (70345974)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 胃癌 / microRNA / 腹膜播種 / 遠隔転移 / micro RNA / 血清 / 予後マーカー / micro RNA |
Outline of Final Research Achievements |
Comprehensive microRNA (miRNA) analysis was analyzed for expression of microRNAs from gastric cancer tumor tissue and normal tissue. MiRNAs involved in epithelial mesenchymal transition correlated with distant metastasis of gastric cancer. Serum miR-203 was identified and it was shown that it was significantly lower in stage IV gastric cancer patients than in stage I - III gastric cancer patients, and this low expression was found to be an independent predictive marker of poor prognosis in gastric cancer patients. The fact that MTA-1 expression in gastric cancer tissues is useful as a peritoneal dissemination predictor, and that the high expression of gastric cancer tissue ANGPTL 2 and the increase in ANGPTL 2 concentration in serum correlate with peritoneal dissemination and are useful for differentiation of poor prognosis group Indicated.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Circulating micro RNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer2016
Author(s)
Hiroki Imaoka, Yuji Toiyama, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Masaki Ohi, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri
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Journal Title
Gastric Cancer
Volume: 19
Issue: 3
Pages: 744-753
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Circulating microRNA-203 predicts metastases, early recurrence, and poor prognosis in human gastric cancer.2015
Author(s)
Imaoka H1, Toiyama Y, Okigami M, Yasuda H, Saigusa S, Ohi M, Tanaka K, Inoue Y, Mohri Y, Kusunoki M.
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Journal Title
gastric cancer
Volume: 2015
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis.2014
Author(s)
Okugawa Y, Toiyama Y, Hur K, Toden S, Saigusa S, Tanaka K, Inoue Y, Mohri Y, Kusunoki M, Boland CR, Goel A.
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Journal Title
Carcinogenesis
Volume: 35
Issue: 12
Pages: 2731-2739
DOI
Related Report
Peer Reviewed
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[Presentation] Circulating microRNA-203 Predicts Metastases, Early Recurrence, and Poor Prognosis in Human Gastric Cancer2015
Author(s)
Yuji Toiyama, Hiroki Imaoka, Masato Okigami, Hiromi Yasuda, Susumu Saigusa, Masaki Ohi, Minako Kobayashi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki
Organizer
DDW 2015
Place of Presentation
Washington, DC(アメリカ)
Year and Date
2015-05-17
Related Report
Int'l Joint Research