Investigation of chemoradiation sensitivity based on the DNA repair mechanism in esophageal carcinoma
| Project/Area Number |
26461980
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
Ito Shuhei 九州大学, 大学病院, 講師 (10706914)
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| Co-Investigator(Kenkyū-buntansha) |
岡野 慎士 九州大学, 医学研究院, 准教授 (10380429)
森田 勝 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 消化器外科部長 (30294937)
北尾 洋之 九州大学, 医学研究院, 准教授 (30368617)
池田 哲夫 九州大学, 大学病院, 准教授 (60585701)
沖 英次 九州大学, 大学病院, 講師 (70380392)
佐伯 浩司 九州大学, 医学研究院, 准教授 (80325448)
中島 雄一郎 九州大学, 医学研究院, 助教 (40733564)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | DNA2重鎖修復 / 染色体不安定性 / 姉妹染色分体交換 / PARP阻害剤 / 腫瘍免疫 / PD-L1 / HLA ClassⅠ / 食道癌 / 化学放射線療法 |
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| Outline of Final Research Achievements |
We quantified cytogenetic alterations of human cells exposed to PARPi by both sister chromatid exchange (SCE) assays and chromosome spreading. Clinically relevant doses of the FDA-approved olaparib led to a marked increase of SCEs (5-10-fold) and chromatid aberrations (2-6-fold). Genomic instability arising from PARPi warrants consideration, especially if these agents will be used in people with early stage cancers, in prevention strategies or for non-oncologic indications.
Programmed cell death 1 ligand 1 (PD-L1) and human leukocyte antigen (HLA) class I molecules on malignant cell surfaces are pivotal for tumor immunity. PD-L1 and HLA class I protein expression was investigated by immunohistochemical staining of resected specimens from 90 ESCC patients who underwent radical surgery without preoperative therapy. High PD-L1 expression was a significant independent prognostic factor in ESCC patients with high HLA class I expression.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma: Prognostic Factors for Patient Outcome.2016
Author(s)
Ito S, Okano S, Morita M, Saeki H, Tsutsumi S, Tsukihara H, Nakashima Y, Ando K, Imamura Y, Ohgaki K, Oki E, Kitao H, Mimori K, Maehara Y.
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Journal Title
Ann Surg Oncol.
Volume: 23(Suppl 4)
Issue: S4
Pages: 508-515
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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