Functional analysis of new biomarkers (Runx3, EZH2) in Gastroesophageal junction cancer
| Project/Area Number |
26461981
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
HIDAKA Shigekazu 長崎大学, 病院(医学系), 講師 (30380885)
NAGAYASU Takeshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80284686)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 食道胃接合部癌 / EZH2 / 胃癌 / 抗ｐ53抗体 / バイオマーカー / RUNX3 |
|---|
| Outline of Final Research Achievements |
Identifying useful biomarkers were essential to select optimal therapeutic strategies for cancer. Quantitative real-time PCR analysis revealed higher expression of EZH2 in clinical gastric cancer tissues than in corresponding non-neoplastic tissues, and we comfirmed that a wide range of cancers also overexpress EZH2, using cDNA microarray analysis. Immunohistochemical analysis showed positive staining (>50%) for EZH2 in 77 of 97 cases of gastric cancer. We could not find elevated expression of EZH2 to be associated with poor prognosis for patients with gastric cancer (P=0.670). Our study has demonstrated that combination of s-p53Ab and other tumor markers can serve as a useful biomarker set of gastrointestinal cancer and should be incorporated into traditional clinical and pathologic variables to complement outcome prediction of gastrointestinal cancer patients after treatment.
|
Report
(5 results)
Research Products
(8 results)
-
[Journal Article] Clinical Value of Serum p53 Antibody in the Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma2018
Author(s)
Kunizaki M, Hamasaki K, Wakata K, Tobinaga S, Sumida Y, Hidaka S, Yasutake T, Miyazaki T, Matsumoto K, Yamasaki T, Sawai T, Hamamoto R, Nanashima A, Nagayasu T.
-
Journal Title
Anticancer Research
Volume: 38
Pages: 1807-1813
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
