New strategy of treatment of hepatoid adenocarcinoma

• Project/Area Number: 26461983
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Miyazaki
• Principal Investigator: Takahashi Nobuyasu 宮崎大学, 医学部, 助教 (20404436)
• Co-Investigator(Kenkyū-buntansha): 豊嶋 典世 (青山典世 / 豊嶋 典世(青山典世)) 宮崎大学, 医学部, 講師 (10468035) ; 澤口 朗 宮崎大学, 医学部, 教授 (30336292)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 肝様腺癌 / 三次元培養 / AFP

Outline of Final Research Achievements

Hepatoid adenocarcinoma is a special type of gastric cancer with high metastasis to the liver bacause of its drug resistance. In the first year of this study, we established a hepatoid adenocarcinoma cell line (Int J Oncol. 2014;44(4):1139-45). Using this cell line and other hepatoid adenocarcinoma cell line, we analysed cellular morphology and function by three dimensional culture. In the future, by this culture method, we are planning to identify and analyse a protein concerning new strategy of treatment of hepatoid adenocarcinoma.

Research Products

• [Journal Article] Establishment and biological characterization of a novel cell line derived from hepatoid adenocarcinoma originated at the ampulla of Vater (2014)
  • Author(s): Takahashi N, Aoyama F, Hiyoshi M, Kataoka H, Sawaguchi A.
  • Journal Title: Int. J. Oncol. Volume: 44 Issue: 4 Pages: 1139-1145
  • DOI: 10.3892/ijo.2014.2282
  • Peer Reviewed / Open Access / Acknowledgement Compliant