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Development of risk stratification kit and small molecular anticancer drug by biomarker of gastric cancer

Research Project

Project/Area Number 26461984
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionYokohama City University

Principal Investigator

OSHIMA Takashi  横浜市立大学, 医学部, 准教授 (10448665)

Research Collaborator NEAMATI Nouri  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胃癌 / バイオマーカー / 新規ターゲット / リスク層別化キット / 低分子抗癌剤
Outline of Final Research Achievements

We searched for the candidates of recurrence risk stratification markers of Stage II/III gastric cancer by quantitative PCR method and exploratory proteomics. 13 genes were identified by the quantitative PCR method, and 4 proteins were identified by exploratory proteomics. Then we examined the expression of these marker candidates by immunostaining using tissue microarray, it was possible to stratify the risk of recurrence with the combination of SPARC, EZH2, ERBB2, p53.
In development of small molecular anticancer drugs targeting KIAA 1199, it was narrowed down to 12 kinds of drugs due to the antitumor effect on gastric cancer cells. We then examinied the effect of combination with 5-FU on gastric cancer by Chou and Talaly method, synergistic effect was confirmed in one drug.We are planning to conduct animal experiments using this drug.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Clinical significance of platelet-derived growth factor receptor-β gene expression in stage II/III gastric cancer with S-1 adjuvant chemotherapy.2017

    • Author(s)
      Higuchi A, Oshima T, Yoshihara K, Sakamaki K, Aoyama T, Suganuma N, Yamamoto N, Sato T, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Kunisaki C, Imada T, Masuda M.
    • Journal Title

      Oncology letters

      Volume: 13 Issue: 2 Pages: 905-911

    • DOI

      10.3892/ol.2016.5494

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of SPARC gene expression in patients with stage II/III gastric cancer after curative resection and adjuvant chemotherapy with S-1.2017

    • Author(s)
      Suzuki Y, Oshima T, Yoshihara K, Sakamaki K, Aoyama T, Suganuma N, Yamamoto N, Sato T, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Kunisaki C, Imada T, Masuda M.
    • Journal Title

      Oncology Letters

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of INHBA gene expression in patients with gastric cancer who underwent curative resection followed by adjuvant chemotherapy with S-12017

    • Author(s)
      Katayama Y, Oshima T, Sakamaki K, Aoyama T, Hayashi T, Yamada T, Sato T, Yamamoto Y, Kunisaki C, Shiozawa M, Yoshikawa T, Akaike M, Rino Y, Imada T, Masuda M
    • Journal Title

      IN VIVO

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of IGF1R gene expression in patients with Stage II/III gastric cancer who receive curative surgery and adjuvant chemotherapy with S-1.2016

    • Author(s)
      Numata K, Oshima T, Sakamaki K, Yoshihara K, Aoyama T, Hayashi T, Yamada T, Sato T, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Kunisaki C, Akaike M, Imada T, Masuda M.
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 142 Issue: 2 Pages: 415-422

    • DOI

      10.1007/s00432-015-2039-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relation of INHBA Gene Expression to Outcomes in Gastric Cancer after Curative Surgery2014

    • Author(s)
      Oshima T, Yoshihara K, Aoyama T, Hasegawa S, Sato T, Yamamoto N, Akito N, Shiozawa M, Yoshikawa T, Numata K, Rino Y, Kunisaki C, Tanaka K, Akaike M, Imada T, Masuda M:
    • Journal Title

      Anticancer Research

      Volume: 34 Pages: 2303-2309

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of overexpression of Sushi repeat-containing protein X-linked 2 gene on outcomes of gastric cancer2014

    • Author(s)
      Yamada T, Oshima T, Yoshihara K, Sato T, Nozaki A, Shiozawa M, Ota M, Yoshikawa T, Akaike M, Numata K, Rino Y, Kunisaki C, Tanaka K, Imada T, Masuda M
    • Journal Title

      Journal of Surgical Oncology

      Volume: 109 Issue: 8 Pages: 836-840

    • DOI

      10.1002/jso.23602

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Search for a combination of recurrence risk stratification markers after curative resection of gastric cancer2017

    • Author(s)
      Oshima T, Kimura Y, Sakamaki K, Miyagi Y, Yamanaka S, Sato T, Shiozawa M, Yoshikawa T, Rino Y, Oue N, Yasui W, Imada T, Masuda M
    • Organizer
      American Association of cancer Research Annual Meeting 2017
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2017-03-31
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Search for biomarkers of Stage II/III gastric cancer using clinical specimens with the goal of personalized therapy2017

    • Author(s)
      大島貴,木村弥生,坂巻顕太郎,宮城洋平,吉川貴己,森田智視,山中正二,長晴彦,塩澤学,利野靖,円谷彰,大上直秀,安井弥,今田敏夫,益田宗孝
    • Organizer
      第89回日本胃癌学会
    • Place of Presentation
      広島国際会議場,広島県広島市
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] StageII/III胃癌根治切除後の再発リスク層別化マーカー検索2016

    • Author(s)
      大島貴,木村弥生,宮城洋平,坂巻顕太郎,山中正二,長晴彦,塩澤学,吉川貴己,利野靖,大上直秀,安井弥,今田敏夫,益田宗孝
    • Organizer
      第54回日本癌治療学会
    • Place of Presentation
      パシフィコ横浜,神奈川県横浜市
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Statification Markers for the Risk of Recurrence after Curative Resection of Stage II or III Gastric Cancer2016

    • Author(s)
      大島貴,木村弥生,坂巻顕太郎,宮城洋平,山中正二,吉川貴己,塩澤学,大上直秀,利野靖,安井弥,今田敏夫,益田宗孝
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      パシフィコ横浜,神奈川県横浜市
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Stratification Markers for the Risk of Recurrence after Curative Resection of Stage II/III Gastric Cancer.2016

    • Author(s)
      Oshima T, Sakamaki K, Miyagi Y, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Kunisaki C, Tsuburaya A, Imada T, Masuda M
    • Organizer
      American Association of cancer Research Annual Meeting 2016
    • Place of Presentation
      New Orleans,USA
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stratification Markers for the Risk of Recurrence after Curative Resection of2016

    • Author(s)
      Oshima T, Sakamaki K, Miyagi Y, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Kunisaki C, Tuburaya A, Imada T, Masuda M
    • Organizer
      American Association of Cancer Research Annual Meeting
    • Place of Presentation
      Ernest N. Morial Convention Center New Orleans, Louisiana, USA
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] StageII/III胃癌根治切除後のリスク層別化マーカー検索と臨床応用2015

    • Author(s)
      大島 貴,木村弥生,中居佑介,坂巻顕太郎,宮城洋平,山中正二,長晴彦,塩澤学,吉川貴己,利野靖,安井弥,今田敏夫,益田宗孝
    • Organizer
      第53回日本癌治療学会
    • Place of Presentation
      国立京都国際会館,京都
    • Year and Date
      2015-10-29 – 2015-10-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] StageII/III胃癌根治切除後のリスク層別化マーカー検索と臨床応用2015

    • Author(s)
      大島貴,木村弥生,中居祐介,坂巻顕太郎,宮城洋平,山中正二,長晴彦,塩沢学,吉川貴己,利野靖,安井弥,今田敏夫,益田宗孝
    • Organizer
      日本癌治療学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Stratification Markers for the Risk of Recurrence after Curative Resection of Stage II or III Gastric Cancer and Potential Clinical Applications2015

    • Author(s)
      Oshima T, Sakamaki K, Miyagi Y, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Kunisaki C, Tuburaya A Imada T, Masuda M
    • Organizer
      American Society of Clinical Oncology Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, Illinois, United States of America.
    • Year and Date
      2015-05-29 – 2015-06-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Stratification Markers for Risk of Recarrence after curative Resection of Stage II or III Gastric Cancer and Potential Clinical Applications.2015

    • Author(s)
      Oshima T, Sakamaki K, Miyagi Y, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Kunisaki C, Tuburaya A, Imada T, Masuda M
    • Organizer
      American Society of Clinical Oncology Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, Illinois, USA
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Assessment of Recurrence Risk Stratification Markers after Resection of Stage II or III Gastric Cancer and Potential Clinical Applications.2014

    • Author(s)
      Oshima T, Sakamaki K, Miyagi Y, Shiozawa M, Kunisaki C, Yoshikawa T, Rino Y, Imada T, Masuda M
    • Organizer
      American Association of Cancer Research Annual Meeting
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, Pennsylvania, United States of America.
    • Year and Date
      2014-04-18 – 2014-04-22
    • Related Report
      2014 Research-status Report
  • [Book] 腫瘍内科2015

    • Author(s)
      大島 貴,吉川貴己
    • Total Pages
      144
    • Publisher
      科学評論社
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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