Gene mutation analysis of esophageal cancer in the era of post genome-sequense
| Project/Area Number |
26461986
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
KIMURA Masahiro 名古屋市立大学, 大学院医学研究科, 研究員 (50336682)
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| Co-Investigator(Kenkyū-buntansha) |
石黒 秀行 名古屋市立大学, 大学院医学研究科, 准教授 (10363920)
田中 達也 名古屋市立大学, 大学院医学研究科, 助教 (20529169)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 次世代シークエンス / 食道癌 |
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| Outline of Final Research Achievements |
Next generataion Sequence was done about 400 genes using Truseq Custum Trial kit (Cancer Gene) for 48 samples of esophageal cancer. We found the mutaion of 7 genes involved T factor (AKAP9, ATM, CYTSB, DDX10, MYH7, MYST4 and PRDM16) Moreover, we found 8 gene mutaion involved N factor (BCR, CARD11, FANCA, JAZF1, NIN, NSD1, RAMBP17 and REQL4).
This result of analysis for these 400 genes were similar to 30,000 genes of whole genomic analysis in other facilities.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats.2015
Author(s)
Sagawa H, Naiki-Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, Sato S, Shiomi K, Kato A, Kuno T, Matsuo Y, Kimura M, Takeyama H, Takahashi S.
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Journal Title
Carcinogenesis
Volume: 36
Pages: 1539-49
DOI
Related Report
Peer Reviewed / Open Access
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