| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We reported in our previous paper that miR-23a, miR27b, miR96, miR128b and miR129 are involved in the prognosis of esophageal cancer patients. Especially, miR34b didn't express in the normal tissue, and had high expression in the cancerous tissue.
Because the target genes of miR34b were DLL1 and NOTCH1, and one of a target of miR27b was NOTCH1, we analyzed NOTCH1pathway in esophageal cancer. We recognized that nuclear expression of NOTCH1 was involved in the poor prognosis of esophageal cancer patients. Therefore, NOTCH signal was important in the esophageal cancer.
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