Analysis of microRNA in esophageal cancer
| Project/Area Number |
26461987
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木村 昌弘 名古屋市立大学, 大学院医学研究科, 研究員 (50336682)
溝口 公士 名古屋市立大学, 大学院医学研究科, 助教 (50722659)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | microRNA / 食道癌 |
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| Outline of Final Research Achievements |
We reported in our previous paper that miR-23a, miR27b, miR96, miR128b and miR129 are involved in the prognosis of esophageal cancer patients. Especially, miR34b didn't express in the normal tissue, and had high expression in the cancerous tissue.
Because the target genes of miR34b were DLL1 and NOTCH1, and one of a target of miR27b was NOTCH1, we analyzed NOTCH1pathway in esophageal cancer. We recognized that nuclear expression of NOTCH1 was involved in the poor prognosis of esophageal cancer patients. Therefore, NOTCH signal was important in the esophageal cancer.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats.2015
Author(s)
Sagawa H, Naiki-Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, Sato S, Shiomi K, Kato A, Kuno T, Matsuo Y, Kimura M, Takeyama H, Takahashi S.
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Journal Title
Carcinogenesis
Volume: 36
Pages: 1539-49
DOI
Related Report
Peer Reviewed / Open Access
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