Effect of microRNA on peritoneal dissemination in gastric cancer
Project/Area Number |
26461989
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
ICHIKAWA DAISUKE 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20347446)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 胃癌 / 腹膜播種 / exosome / microRNA |
Outline of Final Research Achievements |
TEX were internalized in both mesothelial and gastric cancer cells in a cellular origin non-specific manner. Internalization of TEX into mesothelial cells promoted significant adhesion between mesothelial and gastric cancer cells, and TEX internalization into gastric cancer cells significantly promoted migratory ability, while internalization of mesothelial cell-derived exosomes did not. Expression of adhesion-related molecules, such as fibronectin 1 (FN1) and laminin gamma 1 (LAMC1), were increased in mesothelial cells after internalization of TEX from gastric cancer cell line and malignant pleural effusion. TEX may play a critical role in the development of peritoneal metastasis of gastric cancer, which may be partially due to inducing increased expression of adhesion molecules in mesothelial cells.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells2016
Author(s)
Tomohito Arita, Daisuke Ichikawa, Hirotaka Konishi, Shuhei Komatsu, Atsushi Shiozaki, Shinpei Ogino, Yuji Fujita, Hidekazu Hiramoto, Junichi Hamada, Katsutoshi Shoda, Toshiyuki Kosuga, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
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Journal Title
Oncotarget
Volume: 7(35)
Issue: 35
Pages: 56855-56863
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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