The development of molecular target drug through the control of IL23/Th17 pathway in tumor microenvironment.
| Project/Area Number |
26461993
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Wakayama Medical University |
|---|
Principal Investigator |
Iida Takeshi 和歌山県立医科大学, 医学部, 博士研究員 (30453187)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中森 幹人 和歌山県立医科大学, 医学部, 准教授 (10322372)
山上 裕機 和歌山県立医科大学, 医学部, 教授 (20191190)
岡田 健一 和歌山県立医科大学, 医学部, 講師 (50407988)
勝田 将裕 和歌山県立医科大学, 医学部, 助教 (50464673)
谷 眞至 和歌山県立医科大学, 医学部, 准教授 (60236677)
尾島 敏康 和歌山県立医科大学, 医学部, 講師 (60448785)
中村 公紀 和歌山県立医科大学, 医学部, 講師 (80364090)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | IL-17 / IL-23 / IL-21 / 胃癌 / 腫瘍微小環境 / 食道癌 |
|---|
| Outline of Final Research Achievements |
In the patients who underwent curative resection, IL-17 mRNA expression levels in peritoneal lavage increased according to the depth of tumor invasion.
To examine the correlation of IL-17 production between in peritoneal lavage and in the primary tumor tissue, we performed immunohistochemical staining for IL-17 of primary tumor in the same patients samples. In the primary tumor tissues, IL-17 immunoreactive cells were detected at the cytoplasm in mononuclear cells; however none of the tumor cells were stained for IL-17. IL-17 producing cells in tumor tissues were 7.30 ± 0.82 (mean ± SE) per field. There were no correlation between IL-17 positive cells in tumor tissues and IL-17 mRNA expression in peritoneal wash (r=0.092, p=0.329). It was suggested that IL-17 locally expressed in the tumor would be a potential therapeutic target for treatment of patients with advanced gastric cancer.
|
Report
(4 results)
Research Products
(2 results)
