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Investigation of regulating system in histone mRNA and microRNA expression in upper digestive tract cancer

Research Project

Project/Area Number 26461994
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionIwate Medical University

Principal Investigator

Iwaya Takeshi  岩手医科大学, 医学部, 講師 (70405801)

Co-Investigator(Kenkyū-buntansha) 若林 剛  岩手医科大学, 医学部, 教授 (50175064)
西塚 哲  岩手医科大学, 医学部, 教授 (50453311)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsヒストンmRNA / microRNA / 胃癌 / 食道癌 / microRNA 760 / 癌転移浸潤
Outline of Final Research Achievements

Upregulation of multiple histone mRNA and downregulation of several microRNA (miR-760, miR-1276, and miR-4766-5p) which were targeting 3' untranslated regions of histone mRNAs were observed in gastric adenocarcinoma and esophageal squamous cell carcinoma. However, overexpression of these microRNAs could not change the cellular function of histone mRNA expression in cancer cells. Therefore, another mechanism is thought to be involved in regulating histone mRNA and microRNAs except for direct binding od these RNAs. In this study, we proposed a new mechanism that circular RNA might act as microRNA sponges and downregulated histone mRNAs in gastric cancer cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015 2014

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (13 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development.2017

    • Author(s)
      Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K.
    • Journal Title

      Int J Oncol.

      Volume: 50(2) Issue: 2 Pages: 441-447

    • DOI

      10.3892/ijo.2016.3817

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.2016

    • Author(s)
      R. Uchi (他40名, 山本36番目)
    • Journal Title

      PLoS Genetics

      Volume: 12 Issue: 2 Pages: 1-24

    • DOI

      10.1371/journal.pgen.1005778

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population.2016

    • Author(s)
      G. Sawada (他43名, 山本21番目)
    • Journal Title

      Gastroenterology

      Volume: 150 Issue: 5 Pages: 1171-1182

    • DOI

      10.1053/j.gastro.2016.01.035

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF152016

    • Author(s)
      Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS
    • Journal Title

      Sci Rep

      Volume: - Issue: 1 Pages: 25895-25895

    • DOI

      10.1038/srep25895

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.2016

    • Author(s)
      Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, et al
    • Journal Title

      PLoS Genet

      Volume: 18;12(2)

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel.2016

    • Author(s)
      Sato KA, Hachiya T, Iwaya T, Kume K, Matsuo T, Kawasaki K, Abiko Y, Akasaka R, Matsumoto T, Otsuka K, Nishizuka SS
    • Journal Title

      PLoS One

      Volume: 11 Issue: 1 Pages: e0146275-e0146275

    • DOI

      10.1371/journal.pone.0146275

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal epithelial culture under an air-liquid interface: a tool for studying human and mouse esophagi.2015

    • Author(s)
      Yokobori T, Suzuki S, Miyazaki T, Sohda M, Sakai M, Tanaka N, Ozawa D, Hara K, Honjo H, Altan B, Fukuchi M, Ishii H, Iwatsuki M, Sugimachi K, Sudo T, Iwaya T, Nishida N, Mimori K, Kuwano H, Mori M.
    • Journal Title

      Dis Esophagus.

      Volume: [Epub ahead of print] Issue: 7 Pages: 843-847

    • DOI

      10.1111/dote.12346

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyperglycemia 3 days after esophageal cancer surgery is associated with an increased risk of postoperative infection.2014

    • Author(s)
      Ito N, Iwaya T, Ikeda K, Kimura Y, Akiyama Y, Konosu M, Ishida K, Fujiwara H, Otsuka K, Nitta H, Kashiwaba M, Koeda K, Nishizuka S, Mizuno M, Sasaki A, Wakabayashi G.
    • Journal Title

      J Gastrointest Surg

      Volume: 18 (9) Pages: 1547-56

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] .A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines.2014

    • Author(s)
      Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G
    • Journal Title

      Plos One

      Volume: 9 (2) Issue: 2 Pages: e90155-e90155

    • DOI

      10.1371/journal.pone.0090155

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Target sequenceによる食道癌変異遺伝子同定効率に関する検討2017

    • Author(s)
      岩谷 岳,遠藤 史隆, 西塚 哲, 秋山 有史, 塩井 義祐, 高原 武志, 大塚 幸喜, 新田 浩幸, 肥田 圭介, 水野 大, 佐々木 章
    • Organizer
      第117回日本外科学会
    • Place of Presentation
      横浜
    • Year and Date
      2017-04-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma2017

    • Author(s)
      Takeshi Iwaya, Fumitaka Endo, Kohei Kume, Yasushi Sasaki, Takashi Tokino, Satoshi Nishizuka
    • Organizer
      American Association for Cancer Research Annual Meeting 2017
    • Place of Presentation
      Washington, D.C.
    • Year and Date
      2017-04-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mutation detection by target sequence analyses using cancer-related gene p anel in esophageal squamous cell carcinoma2016

    • Author(s)
      Iwaya T, Fumitaka Endo, Kohei Kume, Yasushi Sasaki, Takashi Tokino, Genta Sawada, A tsushi Niida, Koshi Mimori, Satoshi Nishizuka
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibition of phosphatidylinositol 3-kinase suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil2016

    • Author(s)
      Satoshi S. Nishizuka1, Kaoru Ishida1, Yukimi Ohmori1, Kohei Kume1, Chie Ito1, Akari Konta1, Yuka Koizumi1, Mamoru Nukatsuka2, Takashi Kobunai2, Teiji Takechi2, Takeshi Iwaya1
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2016-04-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] TAF15 as an important mediator of RNA polymerase II-dependent drug tolerance2016

    • Author(s)
      Kohei Kume, Kohei Ito, Takeshi Iwaya, Satoshi S. Nishizuka
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2016-04-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiple genes on chromosome 17q25 were involved in sporadic esophageal squamous cell carcinoma development2016

    • Author(s)
      Takeshi Iwaya1, Suburu Amano1, Fumitaka Endo1, Yuji Akiyama1, Yoshihiro Shioi1, Kohei Kume1, Satoshi Nishizuka1, Chie Ito1, Akira Sasaki1, Koshi Mimori2
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2016-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Downregulation of TMPRSS11B in squamous cell carcinoma2016

    • Author(s)
      Suburu Amano, Takeshi Iwaya, Satoshi Nishizuka, Kohei Kume, Chie Ito, Yuji Akiyama, Yoshihiro Shioi, Fumitaka Endo, Akira Sasaki
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2016-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiple genes on chromosome 17q25 were involved in sporadic esophageal sq uamous cell carcinoma development2016

    • Author(s)
      Takeshi Iwaya, Suburu Amano, Fumitaka Endo, Yuji Akiyama, Yoshihiro Shioi, Kohei Kume, Satotshi Nishizuka, Chie Ito, Akira Sasaki, Koshi Mimori
    • Organizer
      American Association for Cancer Research Annual Meeting 2016
    • Place of Presentation
      New Orleans, Louisiana
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 癌細胞・癌関連線維芽細胞におけるヒストンmRNA/microRNA 代謝経路を標的とした癌治療法開発に向けた基礎研究2015

    • Author(s)
      岩谷 岳
    • Organizer
      第17回外科分子細胞治療研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Overexpression of long noncoding RNA FTX was associated with colorectal ca ncer progression2014

    • Author(s)
      岩谷 岳、高橋佑典, 澤田元太, 嶋村徹平, 佐藤慧, 伊藤千恵, 久米浩平, 西塚哲, 秋山有史 , 森正樹, 三森功士, 若林剛
    • Organizer
      第73回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Downregulation of ST6GALNAC1 on chromosome 17q25.1 was associated with esophageal squamous cell carcinoma development / Takeshi Iwaya2014

    • Author(s)
      Takeshi Iwaya, Yuji Akiyama, Masafumi Konosu, Yusuke Kimura, Fumitaka Endo, Keisuke Koeda, Akira Sasaki, Koshi mimori, Go Wakabayashi
    • Organizer
      The International Society for Diseases of the Esophagus
    • Place of Presentation
      バンクーバー
    • Year and Date
      2014-09-22 – 2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 胃癌進展を制御するmicroRNA 760に関する検討2014

    • Author(s)
      岩谷 岳、三森功士, 深川剛生, 秋山有史, 鴻巣正史, 肥田圭介, 西塚哲, 森正樹, 笹子三津 留, 若林剛
    • Organizer
      第69回日本消化器外科学会総会
    • Place of Presentation
      福島
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] MicroRNA 760 regulates gastric cancer progression by downregulation of his tone mRNA expression2014

    • Author(s)
      Takeshi Iwaya, Takeo Fukagawa, Yutaka Suzuki, Tomoya Sudo, Kaoru Ishida, Kohei Kume, Satoshi Nishizuka, Hisae Iinuma, Masaki Mori, Mitsuru Sasako, Go Wakabayashi, Koshi Mimori
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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