Investigation of regulating system in histone mRNA and microRNA expression in upper digestive tract cancer
Project/Area Number |
26461994
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Iwate Medical University |
Principal Investigator |
Iwaya Takeshi 岩手医科大学, 医学部, 講師 (70405801)
|
Co-Investigator(Kenkyū-buntansha) |
若林 剛 岩手医科大学, 医学部, 教授 (50175064)
西塚 哲 岩手医科大学, 医学部, 教授 (50453311)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ヒストンmRNA / microRNA / 胃癌 / 食道癌 / microRNA 760 / 癌転移浸潤 |
Outline of Final Research Achievements |
Upregulation of multiple histone mRNA and downregulation of several microRNA (miR-760, miR-1276, and miR-4766-5p) which were targeting 3' untranslated regions of histone mRNAs were observed in gastric adenocarcinoma and esophageal squamous cell carcinoma. However, overexpression of these microRNAs could not change the cellular function of histone mRNA expression in cancer cells. Therefore, another mechanism is thought to be involved in regulating histone mRNA and microRNAs except for direct binding od these RNAs. In this study, we proposed a new mechanism that circular RNA might act as microRNA sponges and downregulated histone mRNAs in gastric cancer cells.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development.2017
Author(s)
Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K.
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Journal Title
Int J Oncol.
Volume: 50(2)
Issue: 2
Pages: 441-447
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF152016
Author(s)
Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS
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Journal Title
Sci Rep
Volume: -
Issue: 1
Pages: 25895-25895
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing Panel.2016
Author(s)
Sato KA, Hachiya T, Iwaya T, Kume K, Matsuo T, Kawasaki K, Abiko Y, Akasaka R, Matsumoto T, Otsuka K, Nishizuka SS
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Journal Title
PLoS One
Volume: 11
Issue: 1
Pages: e0146275-e0146275
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intestinal epithelial culture under an air-liquid interface: a tool for studying human and mouse esophagi.2015
Author(s)
Yokobori T, Suzuki S, Miyazaki T, Sohda M, Sakai M, Tanaka N, Ozawa D, Hara K, Honjo H, Altan B, Fukuchi M, Ishii H, Iwatsuki M, Sugimachi K, Sudo T, Iwaya T, Nishida N, Mimori K, Kuwano H, Mori M.
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Journal Title
Dis Esophagus.
Volume: [Epub ahead of print]
Issue: 7
Pages: 843-847
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Hyperglycemia 3 days after esophageal cancer surgery is associated with an increased risk of postoperative infection.2014
Author(s)
Ito N, Iwaya T, Ikeda K, Kimura Y, Akiyama Y, Konosu M, Ishida K, Fujiwara H, Otsuka K, Nitta H, Kashiwaba M, Koeda K, Nishizuka S, Mizuno M, Sasaki A, Wakabayashi G.
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Journal Title
J Gastrointest Surg
Volume: 18 (9)
Pages: 1547-56
Related Report
Peer Reviewed / Open Access
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[Presentation] Target sequenceによる食道癌変異遺伝子同定効率に関する検討2017
Author(s)
岩谷 岳,遠藤 史隆, 西塚 哲, 秋山 有史, 塩井 義祐, 高原 武志, 大塚 幸喜, 新田 浩幸, 肥田 圭介, 水野 大, 佐々木 章
Organizer
第117回日本外科学会
Place of Presentation
横浜
Year and Date
2017-04-27
Related Report
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[Presentation] Inhibition of phosphatidylinositol 3-kinase suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil2016
Author(s)
Satoshi S. Nishizuka1, Kaoru Ishida1, Yukimi Ohmori1, Kohei Kume1, Chie Ito1, Akari Konta1, Yuka Koizumi1, Mamoru Nukatsuka2, Takashi Kobunai2, Teiji Takechi2, Takeshi Iwaya1
Organizer
アメリカ癌学会
Place of Presentation
ニューオリンズ
Year and Date
2016-04-20
Related Report
Int'l Joint Research
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[Presentation] Multiple genes on chromosome 17q25 were involved in sporadic esophageal sq uamous cell carcinoma development2016
Author(s)
Takeshi Iwaya, Suburu Amano, Fumitaka Endo, Yuji Akiyama, Yoshihiro Shioi, Kohei Kume, Satotshi Nishizuka, Chie Ito, Akira Sasaki, Koshi Mimori
Organizer
American Association for Cancer Research Annual Meeting 2016
Place of Presentation
New Orleans, Louisiana
Year and Date
2016-04-16
Related Report
Int'l Joint Research
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[Presentation] Overexpression of long noncoding RNA FTX was associated with colorectal ca ncer progression2014
Author(s)
岩谷 岳、高橋佑典, 澤田元太, 嶋村徹平, 佐藤慧, 伊藤千恵, 久米浩平, 西塚哲, 秋山有史 , 森正樹, 三森功士, 若林剛
Organizer
第73回日本癌学会総会
Place of Presentation
横浜
Year and Date
2014-09-25 – 2014-09-27
Related Report
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[Presentation] MicroRNA 760 regulates gastric cancer progression by downregulation of his tone mRNA expression2014
Author(s)
Takeshi Iwaya, Takeo Fukagawa, Yutaka Suzuki, Tomoya Sudo, Kaoru Ishida, Kohei Kume, Satoshi Nishizuka, Hisae Iinuma, Masaki Mori, Mitsuru Sasako, Go Wakabayashi, Koshi Mimori
Organizer
アメリカ癌学会
Place of Presentation
サンディエゴ
Year and Date
2014-04-05 – 2014-04-09
Related Report