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Downregulation of TMPRSS11B in esophageal squamous cell carcinoma

Research Project

Project/Area Number 26461995
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionIwate Medical University

Principal Investigator

Akiyama Yuji  岩手医科大学, 医学部, 講師 (10405798)

Co-Investigator(Kenkyū-buntansha) 岩谷 岳  岩手医科大学, 医学部, 講師 (70405801)
西塚 哲  岩手医科大学, 医学部, 教授 (50453311)
若林 剛  岩手医科大学, 医学部, 教授 (50175064)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords食道癌 / 癌抑制遺伝子 / 膜結合型セリンプロテアーゼ / TMPRSS11B / 膜型セリンプロテアーゼ / TMPRSS11 / (1) 食道癌 / 遺伝子発現
Outline of Final Research Achievements

This study aims to identify the genes responsible for esophageal squamous cell carcinoma (ESCC) development, using gene expression profiling. Our transcriptome sequence analysis of surgically resected tumors and the corresponding normal tissues from 3 patients with ESCC revealed that transmembrane protease serine 11 (TMPRSS11) subfamily genes showed decreased expression in ESCC tissues. A quantitative reverse transcription PCR demonstrated a downregulation of TMPRSS11B in ESCC tissues, compared with its expression in the corresponding normal tissues (n = 64, p < 0.0001 ). There was no significant difference in the clinico-pathological factors between TMPRSS11B - high and TMPRSS11B -low expression groups. Moreover, TMPRSS11B expression was not detected in any of the 10 ESCC cell lines investigated, and overexpression of TMPRSS11B induced downregulation of EGFR and Akt in the ESCC cell line KYSE410. Our results suggest that TMPRSS11B has tumor suppressive roles in ESCC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results,  Open Access: 4 results) Presentation (14 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 食道扁平上皮癌におけるTransmembrane Protease Serine 11Bの発現抑制に関する検討2017

    • Author(s)
      天野総、岩谷岳、秋山有史
    • Journal Title

      The Journal of the Iwate Medical Association

      Volume: 69 (1) Pages: 1-11

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stability of Cervical Esophagogastrostomy via Hand-sewn Anastomosis after Esophagectomy for Esophageal Cancer.2017

    • Author(s)
      Akiyama Y, Iwaya T, Endo F, Shioi Y, Chiba T, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Kimura Y, Sasaki A.
    • Journal Title

      Dis Esophagus.

      Volume: 30(5) Pages: 1-7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effectiveness of neoadjuvant chemotherapy with cisplatin and irinotecan followed by surgery on small-cell carcinoma of the esophagus: A case report.2015

    • Author(s)
      Akiyama Y
    • Journal Title

      Int J Surg Case Rep.

      Volume: 30 Pages: 121-125

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Successfully treated advanced esophageal cancer with left axillary lymph node metastasis and synchronous right breast cancer: a case report.2015

    • Author(s)
      Akiyama Y
    • Journal Title

      Surg Case Rep.

      Volume: 1 Pages: 94-100

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Curative two-stage resection for synchronous triple cancers of the esophagus, colon, and liver: report of a case.2015

    • Author(s)
      Akiyama Y
    • Journal Title

      Int J Surg Case Rep.

      Volume: 30 Pages: 1-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperglycemia 3 days after esophageal cancer surgery is associated with an increased risk of postoperative infection.2014

    • Author(s)
      12.Ito N, Iwaya T, Ikeda K, Kimura Y, Akiyama Y, Konosu M, Ishida K, Fujiwara H, Otsuka K, Nitta H, Kashiwaba M, Koeda K, Nishizuka S, Mizuno M, Sasaki A, Wakabayashi G.
    • Journal Title

      J Gastrointest Surg.

      Volume: 18 Pages: 1547-56

    • Related Report
      2014 Research-status Report
  • [Journal Article] Totally laparoscopic total gastrectomy for gastric cancer: Literature review and comparison of the procedure of esophagojejunostomy.2014

    • Author(s)
      13.Umemura A, Koeda K, Sasaki A, Fujiwara H, Kimura Y, Iwaya T, Akiyama Y, Wakabayashi G.
    • Journal Title

      Asian J Surg

      Volume: - Issue: 2 Pages: 102-112

    • DOI

      10.1016/j.asjsur.2014.09.006

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Presentation] 胸腔鏡下食道切除術における合併症軽減のための工夫2016

    • Author(s)
      秋山有史,岩谷 岳,遠藤史隆,塩井義裕,高原武志,大塚幸喜,肥田圭介,木村祐輔,佐々木 章
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2016-07-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食道癌に対する周術期の多職種チーム医療介入の成果2016

    • Author(s)
      秋山有史,岩谷 岳,遠藤史隆,塩井義裕,肥田圭介,木村祐輔,佐々木 章
    • Organizer
      第70回日本食道学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] Downregulation of TMPRSS11B in squamous cell carcinoma2016

    • Author(s)
      天野 総
    • Organizer
      アメリカ癌学会
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2016-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Downregulation of TMPRSS11B in squamous cell carcinoma2016

    • Author(s)
      Suburu Amano, Takeshi Iwaya, Satoshi Nishizuka, Kohei Kume, Chie Ito, Yuji Akiyama,
    • Organizer
      アメリカ癌学会 2016
    • Place of Presentation
      ニューオリンズ
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食道扁平上皮癌におけるTransmembrane Protease Serine 11Bの発現異常2016

    • Author(s)
      天野 総
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるTransmenbrane Protease Serine 11Bの発現異常2016

    • Author(s)
      天野総、岩谷岳、西塚哲、秋山有史
    • Organizer
      第116回日本外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食道癌に対する腹臥位胸腔鏡下食道切除術の手術成績2016

    • Author(s)
      秋山有史,岩谷 岳,塩井義裕,遠藤史隆,千葉丈広,大塚幸喜,新田浩幸,肥田圭介,水野 大,木村祐輔,佐々木 章
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腹臥位胸腔鏡下食道亜全摘術における縦隔リンパ節郭清の手術手技2015

    • Author(s)
      秋山 有史
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 腹臥位胸腔鏡下食道亜全摘術における上縦隔郭清の工夫2015

    • Author(s)
      秋山 有史
    • Organizer
      第69回日本食道学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 腹臥位胸腔鏡下食道切除術の定型化.2015

    • Author(s)
      秋山 有史
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 演題食道癌手術における胃管再建の安全な頸部手縫い吻合の手技と成績2014

    • Author(s)
      282.秋山有史,木村祐輔,岩谷 岳,鴻巣正史,藤原久貴,肥田圭介,西塚 哲,大塚幸喜,新田浩幸,柏葉匡寛,佐々木 章,水野 大,若林 剛.
    • Organizer
      第76回日本臨床外科学会総会
    • Place of Presentation
      郡山
    • Year and Date
      2014-11-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 食道癌に対する腹臥位胸腔鏡下食道切除術の定型化~腹臥位のメリットを生かした2014

    • Author(s)
      281.秋山有史,木村祐輔,岩谷 岳,鴻巣正史,藤原久貴,肥田圭介,西塚 哲,大塚幸喜,新田浩幸,柏葉匡寛,佐々木 章,水野 大,若林 剛.
    • Organizer
      第27回日本内視鏡外科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] チームによる食道癌の周術期リハビリテーションの取り組み2014

    • Author(s)
      280.秋山有史,木村祐輔,岩谷 岳,鴻巣正史,藤原久貴,肥田圭介,西塚 哲,大塚幸喜,新田浩幸,柏葉匡寛,佐々木 章,水野 大,若林 剛.
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 食道癌に対する腹臥位胸腔鏡下食道切除術の工夫と治療成績.2014

    • Author(s)
      268.秋山有史,木村祐輔,岩谷 岳,鴻巣正史,藤原久貴,肥田圭介,西塚 哲,大塚幸喜,新田浩幸,柏葉匡寛,佐々木 章,水野 大,若林 剛.
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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