| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In the present study, we investigated miRNA expression profile and function in CSC-like clones and serum derived from esophageal squamous cell carcinoma (ESCC) patients. The result exhibited common 67 miRNAs differentially expressed between CSC-like clones and their parent cell lines. The genes predicted to be targets of candidate miRNAs were chosen and analyzed using the database of miRNA.org site. miR-125a-5p has important roles in docetaxel resistance by regulating protein expression of the ICIS gene. Analysis of comprehensive expression of miRNA in serum was performed using the 3D-Gene system. Between lymph node metastasis group and non-metastasis group, 33 miRNAs significantly showed expression fluctuation. These findings suggest that it may be helpful to develop novel strategies for targeted therapies in ESCC patients.
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