| Project/Area Number |
26461997
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai University |
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Principal Investigator |
NOMURA Eiji 東海大学, 医学部, 教授 (30288732)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 正志 東海大学, 医学部, 助教 (10548647)
向井 正哉 東海大学, 医学部, 教授 (40229919)
中村 健司 東海大学, 医学部, 准教授 (90246116)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Keywords | 胃癌術後再建法 / Quality of Life / 術後機能評価 / ホルモン分泌動態 / 小腸吸収動態 / 早期胃癌 / 腹腔鏡下噴門側胃切除術 / ダブルトラクト法再建 / 空腸間置法再建 / アセトアミノフェン法 / 生理的小腸吸収動態 / 生理的ホルモン分泌動態 / 機能温存手術 / 胃上部早期胃癌標準術式 |
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| Outline of Final Research Achievements |
Functional outcomes were compared between double tract reconstruction (L-DT, n=15) and jejunal interposition reconstruction (L-JIP, n=15) following laparoscopic proximal gastrectomy (LPG), including laparoscopic total gastrectomy with Roux-en-Y reconstruction (L-TG, n=30) as a control group. Investigations of quality of life (QOL) using a questionnaire and endoscopic examination were performed in each patient, and functional evaluations (kinetics of intestinal absorption and hormonal secretion) were carried out in 10 patients in each group. In comparison to L-TG, L-JIP and L-DT are procedures that maintain nearly preoperative gradual intestinal absorption, and they achieve better postoperative QOL as FPG procedures. Furthermore, the intestinal absorption in the L-DT was not affected by the posture of meal intake, so that L-DT might be superior procedure.
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