Functional outcomes by reconstruction technique following laparoscopic proximal gastrectomy for gastric cancer
| Project/Area Number |
26461997
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai University |
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Principal Investigator |
NOMURA Eiji 東海大学, 医学部, 教授 (30288732)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 正志 東海大学, 医学部, 助教 (10548647)
向井 正哉 東海大学, 医学部, 教授 (40229919)
中村 健司 東海大学, 医学部, 准教授 (90246116)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
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| Keywords | 胃癌術後再建法 / Quality of Life / 術後機能評価 / ホルモン分泌動態 / 小腸吸収動態 / 早期胃癌 / 腹腔鏡下噴門側胃切除術 / ダブルトラクト法再建 / 空腸間置法再建 / アセトアミノフェン法 / 生理的小腸吸収動態 / 生理的ホルモン分泌動態 / 機能温存手術 / 胃上部早期胃癌標準術式 |
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| Outline of Final Research Achievements |
Functional outcomes were compared between double tract reconstruction (L-DT, n=15) and jejunal interposition reconstruction (L-JIP, n=15) following laparoscopic proximal gastrectomy (LPG), including laparoscopic total gastrectomy with Roux-en-Y reconstruction (L-TG, n=30) as a control group. Investigations of quality of life (QOL) using a questionnaire and endoscopic examination were performed in each patient, and functional evaluations (kinetics of intestinal absorption and hormonal secretion) were carried out in 10 patients in each group. In comparison to L-TG, L-JIP and L-DT are procedures that maintain nearly preoperative gradual intestinal absorption, and they achieve better postoperative QOL as FPG procedures. Furthermore, the intestinal absorption in the L-DT was not affected by the posture of meal intake, so that L-DT might be superior procedure.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Exploratory phase Ⅱ trial in a multicenter setting to evaluate the clinical value of a chemosensitivity test in patients with gastric cancer (JACCRO-GC 04, Kubota memorial trial)2015
Author(s)
Tanigawa N, Yamaue H, Ohyama S, Sakuramoto S, Inada T, Kodera Y, Kitagawa Y, Omura K, Terashima M, Sakata Y, Nashimoto A, Yamaguchi T, Chin K Nomura E, Lee SW, Takeuchi M, Fujii M, Nakajima T
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Journal Title
Gastric Cancer
Volume: 19
Pages: 350-360
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] A Prospective, Single-Arm, Single-Center, Case Series to Determine the Feasibility of Safe Skill Transfer for Transabdominal Preperitoneal (TAPP) Repair Utilizing a Hands-On Mentorship Model2015
Author(s)
Yamazaki M, Nomura E, Uchida K, Higamai S, Noguchi W, Uda S, Yamamoto S, Tobita K, Mukai M, Makuuchi H
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Journal Title
Tokai J Exp Clin Med
Volume: 40
Pages: 161-164
Related Report
Peer Reviewed
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[Presentation] 胃上部癌に対する腹腔鏡下胃切除術後再建における合併症の予防と治療2015
Author(s)
野村栄治, 谷田部健太郎, 日上滋雄, 宇田周司, 横山大樹, 庫本達, 町田隆志, 茅野新, 福光寛, 幕内博康, 中村健司, 鍋島一仁, 李相雄, 河合英, 内山和久
Organizer
第77回日本臨床外科学会総会
Place of Presentation
福岡国際会議場（福岡県福岡市）
Year and Date
2015-11-26
Related Report
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[Presentation] 腹腔鏡下噴門側胃切除術後再建法の工夫―ダブルトラクト法と空腸間置法―2015
Author(s)
野村栄治, 谷田部健太郎, 日上滋雄, 宇田周司, 横山大樹, 庫本達, 町田隆志, 茅野新, 福光寛, 幕内博康, 中村健司, 鍋島一仁, 李相雄, 河合英, 内山和久
Organizer
第28回日本内視鏡外科学会総会
Place of Presentation
大阪国際会議場（大阪府大阪市）
Year and Date
2015-10-10
Related Report
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