| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
An exome analysis of cancer related more than 400 genes was applied using Ion Torrent Proton and Ion Torrent PGM sequencers in more than 100 gastric cancer cases. Non-synonymous or non-sense germ-line variants correlated with gastric cancer cases was identified as candidate risk factors of gastric cancer in our previous population study. Many somatic mutations, germ-line variants and the copy number variants were identified by the next generation sequencing analysis. Although no relationship between these variants and clinical manifestations has been detected, non-synonymous germ-line variants was identified with a higher frequency. Further analysis is needed to study the mechanisms behind increased gastric cancer risks including possible functional polymorphisms we identified.
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