| Project/Area Number |
26462004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHKOHCHI Nobuhiro 筑波大学, 医学医療系, 教授 (40213673)
ODA Tatsuya 筑波大学, 医学医療系, 教授 (20282353)
MURATA Soichiro 横浜市立大学, 大学院医学研究科, 准教授 (40436275)
TAKEUCHI Tomoyo 筑波大学, 医学医療系, 助教 (50450333)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 直腸癌 / 術前化学放射線療法 / CD44variant 9 / 癌幹細胞 / 大腸癌 / 新規診断法 / CD44v9 / 直腸癌局所再発 |
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| Outline of Final Research Achievements |
Introduction: CD44 variant 9 is important factor of cancer stem cell in colorectal cancer, however, its clinical role is uncertain.Aims: Objective of this study is to evaluate the immune-histochemical expression of CD44 variant 9 as stem cell marker in the colorectal cancer after treatment of neoadjuvant chemoradiotherapy (NCRT). Material and Methods: This study included 20 rectal specimens. All specimens were underwent NCRT. Clinical data were available for all case.Result: Average score of Expression of CD44 after NCRT is 0.93 (0-2.4). Expression score of CD44 variant 9 is in proportion to efficacy of pathological grade; grade2/ 1a/ 0 is 0.3/1.6/2, respectively. However, Expression score of relapse patient, non-relapse patient is 0.8 and 0.93, respectively. The correlation between relapse of tumor and expression of CD44 variant 9 is not significant.Conclusion: Expression of CD44 variant 9 might be associated with treatment effect of NCRT, however, no relation to prognosis.
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