| Project/Area Number |
26462008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今野 弘之 浜松医科大学, 医学部, 学長 (00138033)
菊池 寛利 浜松医科大学, 医学部, 助教 (70397389)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 大腸癌肝転移 / 脂肪酸代謝 |
|---|
| Outline of Final Research Achievements |
In the mouse model of colon cancer liver metastasis, we compared the lipid metabolism profiling between primary tumor and liver metastases by liquid chromatography. However, no significant differences were observed in this experiment. Using the same mouse model, we performed the gene expression analysis by microarray. However, we could not observe any significant differences between primary tumor and liver metastases. Next, we analyzed the protein expression levels that involved in lipid metabolism in surgically resected colon cancer liver metastasis samples by immunohistochemical staining. However, we could not observe any significant differences between primary tumor and liver metastases.
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