Feasibility and efficacy of autologous adipose-derived stem cell therapy for inflammatory bowel disease patients

• Project/Area Number: 26462012
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka University
• Principal Investigator: Mizushima Tsunekazu 大阪大学, 医学系研究科, 寄附講座教授 (00527707)
• Co-Investigator(Kenkyū-buntansha): 西村 潤一 大阪大学, 医学系研究科, 助教 (20379209) ; 飯島 英樹 大阪大学, 医学系研究科, 准教授 (90444520)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 炎症性腸疾患 / 潰瘍性大腸炎 / クローン病 / 脂肪由来幹細胞 / 脂肪組織由来幹細胞

Outline of Final Research Achievements

The number of adipose-derived stem cells contained in the subcutaneous adipose tissue of inflammatory bowel disease (IBD) patients was significantly larger than that of Non-IBD patients. Autologous subcutaneous adipose tissue derived stem cell transplantation for refractory postoperative enterocutaneous fistula could be safely performed on IBD patients and was effective in the short term. In experiments using murine adipose-derived stem cells, proliferation and motility were significantly enhanced by the addition of TNF-α.

Research Products

• [Journal Article] 【消化管の再生医療】 脂肪組織由来幹細胞を用いた消化管再生医療 (2016)
  • Author(s): 水島恒和，深田唯史，土岐祐一郎，森 正樹
  • Journal Title: Med Sci Digest Volume: 42 Pages: 77-80
• [Journal Article] A clinical trial of autologous adipose‑derived regenerative cell transplantation for a postoperative enterocutaneous fistula (2015)
  • Author(s): Mizushima T
  • Journal Title: Surg Today Volume: In press Issue: 7 Pages: 835-842
  • DOI: 10.1007/s00595-015-1246-8
  • Peer Reviewed / Open Access
• [Presentation] 術後難治性皮膚瘻に対する自己脂肪組織由来間葉系前駆細胞移植術の臨床応用 (2016)
  • Author(s): 水島恒和，土岐祐一郎，森 正樹
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 東京都
  • Year and Date: 2016-04-22
• [Presentation] 術後難治性皮膚瘻に対する自己脂肪組織由来間葉系前駆細胞移植術の臨床応用 (2016)
  • Author(s): 水島恒和，竹政伊知朗，畑 泰司，西村潤一，原口直紹，高橋秀和，竹山廣志，内藤 敦，深田唯史，山本浩文，土岐祐一郎，森 正樹
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2016-04-14
• [Presentation] 術後難冶性皮膚瘻に対する自己脂肪組織由来間葉系前駆細胞移植療法の臨床応用 (2015)
  • Author(s): 水島恒和
  • Organizer: 第69回手術手技研究会
  • Place of Presentation: 高崎市
  • Year and Date: 2015-05-16