Feasibility and efficacy of autologous adipose-derived stem cell therapy for inflammatory bowel disease patients
Project/Area Number |
26462012
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
西村 潤一 大阪大学, 医学系研究科, 助教 (20379209)
飯島 英樹 大阪大学, 医学系研究科, 准教授 (90444520)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 炎症性腸疾患 / 潰瘍性大腸炎 / クローン病 / 脂肪由来幹細胞 / 脂肪組織由来幹細胞 |
Outline of Final Research Achievements |
The number of adipose-derived stem cells contained in the subcutaneous adipose tissue of inflammatory bowel disease (IBD) patients was significantly larger than that of Non-IBD patients. Autologous subcutaneous adipose tissue derived stem cell transplantation for refractory postoperative enterocutaneous fistula could be safely performed on IBD patients and was effective in the short term. In experiments using murine adipose-derived stem cells, proliferation and motility were significantly enhanced by the addition of TNF-α.
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Report
(4 results)
Research Products
(5 results)