Micro RNAs as promising therapeutic targets for anti-metastatic therapy in colorectal cancer
| Project/Area Number |
26462016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
Mori Yoshiko 岡山大学, 医歯薬学総合研究科, 助教 (70708081)
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| Co-Investigator(Kenkyū-buntansha) |
楳田 祐三 岡山大学, 大学病院, 助教 (10573735)
永坂 岳司 岡山大学, 大学病院, 講師 (30452569)
中村 圭一郎 岡山大学, 大学病院, 講師 (90359886)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マイクロＲＮＡ / バイオマーカー / 大腸癌 / マイクロRNA |
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| Outline of Final Research Achievements |
The MiRNA array analysis revealed that a set of miRNAs was specifically down-regulated in CRC with BRAF V600E mutation without MSI, considered to be the The MiRNA array analysis revealed that a set of miRNAs was specifically down-regulated in CRC with BRAF V600E mutation without MSI, considered to be the poorer outcome. In vitro, cell lines transfected the set of the miRNAs significantly reduced their malignant potentials. Finally, we analyzed expression level of the set of miRNAs in a cohort of 67 stage IV CRCs. CRCs with the lower expression level of the set of miRNAs showed poor outcome compared with those with the higher expression level. Our data indicate that the miRNAs is promising prognostic biomarkers and therapeutic targets for anti-metastatic therapy in CRC.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms.2016
Author(s)
Yoshida K, Nagasaka T, Umeda Y, Tanaka T, Kimura K, Taniguchi F, Fuji T, Shigeyasu K, Mori Y, Yanai H, Yagi T, Goel A, Fujiwara T.
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Journal Title
J Cancer Res Clin Oncol.
Volume: -
Issue: 7
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.2015
Author(s)
Shigeyasu K, Nagasaka T, Mori Y, Yokomichi N, Kawai T, Fuji T, Kimura K, Umeda Y, Kagawa S, Goel A, Fujiwara T
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Journal Title
PLoS One
Volume: 10
Issue: 6
Pages: e0130409-e0130409
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Modified FOLFOXIRIの当院における有効性と安全性2016
Author(s)
母里 淑子, 永坂 岳司, 河合 毅, 岸本 浩行, 吉岡 貴裕, 佃 和宣, 中谷 紳, 嶋村 廣視, 冨岡 憲明, 森谷 行利, 瀧上 隆夫, 藤原 俊義
Organizer
第71回日本大腸肛門病学会学術集会
Place of Presentation
三重県
Year and Date
2016-11-18
Related Report
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[Presentation] StageIV大腸がんの治療 遺伝子変異情報を考慮したStageIV大腸癌に対する予後の検討及び治療戦略の構築2016
Author(s)
永坂 岳司, 母里 淑子, 岸本 浩行, 神原 健, 河合 毅, 中谷 紳, 嶋村 廣視, 富岡 憲明, 森谷 行利, 瀧上 隆夫, 佃 和憲, 藤原 俊義
Organizer
第71回日本大腸肛門病学会学術集会
Place of Presentation
三重県
Year and Date
2016-11-18
Related Report
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[Presentation] Clinical role of promoter hypermethylation in the MGMT gene during colorectal tumorigenesis2014
Author(s)
Nagasaka T, Mori Y, Umeda Y, Takehara Y, Kawai T, Taniguchi F, Fuji T, Toshima T, Inada R, Kondo Y, OharaT, Kishimoto H, Nishizaki M, Kagawa S, Shirakawa Y, Yagi T, Fujiwara T
Organizer
第25回日本消化器癌発生学会総会・第8回国際消化器癌発生会議
Place of Presentation
福岡市
Year and Date
2014-11-14
Related Report
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[Presentation] StageⅣ大腸がんの予後マーカーとしてのMGMTメチル化ステータスの有用性2014
Author(s)
母里淑子, 永坂岳司, 稲田 涼, 戸嶋俊明, 竹原裕子, 中谷 紳, 竹原清人, 森川達也, 久保田暢人, 宇野 太, 滝上隆夫, 嶋村廣視, 森谷行利, 富岡憲明, 藤原俊義
Organizer
第69回日本大腸肛門病学会学術集会
Place of Presentation
横浜市
Year and Date
2014-11-08
Related Report
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[Presentation] Hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter as a prognostic biomarker for stage Ⅱ,Ⅲ and Ⅳcolorectal cancers2014
Author(s)
Mori Y, Nagasaka T, Umeda Y, Shiwaku R. Inada R, Nishida N, Kishimoto H, Kagawa S, Tanioka H, Mishima H, Fujiwara T, Goel A
Organizer
ESMO 2014 Congress
Place of Presentation
Madrid
Year and Date
2014-09-28
Related Report
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[Presentation] Cytokeratin 19, a novel prognostic biomarker for hepatocellular carcinoma, is regulated by DNA methylation2014
Author(s)
Yokomichi N, Nagasaka T, Nishida N, Taniguchi F, Yoshida K, Tomokazu F, Kawai T, Takehara Y, Kimura K, Mori Y, Inada R, Umeda Y, Yagi T, Goel A, Fujiwara T
Organizer
ESMO 2014 Congress
Place of Presentation
Madrid
Year and Date
2014-09-28
Related Report
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[Presentation] Extensive methylation of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) promoter could predict malignant formation in intraductal papillary mucinous neoplasms (IPMN)2014
Author(s)
Yoshida K, Nagasaka T, Umeda Y, Yokomichi N, Mori Y, Takehara Y, Takehara K, Kawai T, Tomokazu F, Taniguchi F, Yagi T, Goel A, Fujiwara T
Organizer
ESMO 2014 Congress
Place of Presentation
Madrid
Year and Date
2014-09-28
Related Report
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[Presentation] 臨床病期Ⅱ＆Ⅲ直腸癌の遺伝子変異情報及び臨床病理学的所見と予後の検討2014
Author(s)
永坂岳司, 岸本浩行, 母里淑子, 稲田 涼, 近藤喜太, 竹原裕子, 河合 毅, 藤 智和, 谷口文崇, 横道直佑, 久保田暢人, 吉田一博, 楳田祐三, 八木孝仁, 藤原俊義
Organizer
第５２回日本癌治療学会学術集会
Place of Presentation
横浜市
Year and Date
2014-08-29
Related Report
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[Presentation] 遺伝子変異情報を用いた直腸癌局所再発症例に対する治療戦略の検討2014
Author(s)
永坂岳司, 母里淑子, 楳田祐三, 稲田 涼, 森川達也, 横道直佑, 久保田暢人, 吉田一博, 竹原裕子, 河合 毅, 藤 智和, 竹原清人, 杭瀬 崇, 谷口文崇, 近藤喜太, 岸本浩行, 浅野博昭, 佃 憲和, 貞森 裕, 八木孝仁, 藤原俊義
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
京都市
Year and Date
2014-04-03 – 2014-04-05
Related Report
