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Micro RNAs as promising therapeutic targets for anti-metastatic therapy in colorectal cancer

Research Project

Project/Area Number 26462016
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOkayama University

Principal Investigator

Mori Yoshiko  岡山大学, 医歯薬学総合研究科, 助教 (70708081)

Co-Investigator(Kenkyū-buntansha) 楳田 祐三  岡山大学, 大学病院, 助教 (10573735)
永坂 岳司  岡山大学, 大学病院, 講師 (30452569)
中村 圭一郎  岡山大学, 大学病院, 講師 (90359886)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsマイクロRNA / バイオマーカー / 大腸癌 / マイクロRNA
Outline of Final Research Achievements

The MiRNA array analysis revealed that a set of miRNAs was specifically down-regulated in CRC with BRAF V600E mutation without MSI, considered to be the The MiRNA array analysis revealed that a set of miRNAs was specifically down-regulated in CRC with BRAF V600E mutation without MSI, considered to be the poorer outcome. In vitro, cell lines transfected the set of the miRNAs significantly reduced their malignant potentials. Finally, we analyzed expression level of the set of miRNAs in a cohort of 67 stage IV CRCs. CRCs with the lower expression level of the set of miRNAs showed poor outcome compared with those with the higher expression level. Our data indicate that the miRNAs is promising prognostic biomarkers and therapeutic targets for anti-metastatic therapy in CRC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (33 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (30 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms.2016

    • Author(s)
      Yoshida K, Nagasaka T, Umeda Y, Tanaka T, Kimura K, Taniguchi F, Fuji T, Shigeyasu K, Mori Y, Yanai H, Yagi T, Goel A, Fujiwara T.
    • Journal Title

      J Cancer Res Clin Oncol.

      Volume: - Issue: 7 Pages: 1-13

    • DOI

      10.1007/s00432-016-2164-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer.2015

    • Author(s)
      Shigeyasu K, Nagasaka T, Mori Y, Yokomichi N, Kawai T, Fuji T, Kimura K, Umeda Y, Kagawa S, Goel A, Fujiwara T
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0130409-e0130409

    • DOI

      10.1371/journal.pone.0130409

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aggressive multimodality treatment for advanced rectal cancer.2015

    • Author(s)
      Inada R, Nagasaka T, Toshima T, Mori Y, Kondo Y, Kishimoto H, Kiraki T, Oshiro T, Kanemitsu Y, Fujiwara T
    • Journal Title

      Acta Med Okayama

      Volume: 69 Pages: 113-8

    • NAID

      120005595792

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Modified FOLFOXIRIの当院における有効性と安全性2016

    • Author(s)
      母里 淑子, 永坂 岳司, 河合 毅, 岸本 浩行, 吉岡 貴裕, 佃 和宣, 中谷 紳, 嶋村 廣視, 冨岡 憲明, 森谷 行利, 瀧上 隆夫, 藤原 俊義
    • Organizer
      第71回日本大腸肛門病学会学術集会
    • Place of Presentation
      三重県
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] StageIV大腸がんの治療 遺伝子変異情報を考慮したStageIV大腸癌に対する予後の検討及び治療戦略の構築2016

    • Author(s)
      永坂 岳司, 母里 淑子, 岸本 浩行, 神原 健, 河合 毅, 中谷 紳, 嶋村 廣視, 富岡 憲明, 森谷 行利, 瀧上 隆夫, 佃 和憲, 藤原 俊義
    • Organizer
      第71回日本大腸肛門病学会学術集会
    • Place of Presentation
      三重県
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転移性大腸癌における治療標的となりうるマイクロRNAの同定2016

    • Author(s)
      河合 毅, 永坂 岳司, 藤 智和, 戸嶋 俊明, 安井 和也, 母里 淑子, 藤原 俊義
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] IDH1/2およびKRAS遺伝子の変異ステータスによる肝内胆管癌の層別化2016

    • Author(s)
      安井 和也, 永坂 岳司, 楳田 祐三, 藤 智和, 戸嶋 俊明, 河合 毅, 母里 淑子, 八木 孝仁, 藤原 俊義
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] circulating cell free DNAのメチル化解析による大腸癌化学療法の治療効果判定の診断2016

    • Author(s)
      戸嶋 俊明, 永坂 岳司, 木村 圭佑, 安井 和也, 河合 毅, 母里 淑子, 藤原 俊義
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] 岡山大学におけるがんクリニカルシークエンスの臨床実装-抗がん剤適応遺伝子検査外来2016

    • Author(s)
      母里淑子,田端雅弘,西森久和,久保寿夫,枝園和彦,森田瑞樹,冨田秀太,江見裕美,峠和美,豊岡伸一
    • Organizer
      第二回クリニカルバイオバンク研究会シンポジウム
    • Place of Presentation
      北海道
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 難治性固形癌のためのオーダーメイド医療 Orthodox & Serendipity 転移性結腸直腸癌における抗上皮増殖因子受容体治療に対する獲得耐性(Tailor-made medicine for refractory solid carcinoma: Orthodox & Serendipity Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer)2016

    • Author(s)
      谷口 文崇, 永坂 岳司, 藤 智和, 母里 淑子, 岸本 浩行, 河合 毅, 楳田 祐三, 藤原 俊義
    • Organizer
      第71回日本消化器外科学会
    • Place of Presentation
      徳島県
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Micro RNAs as promising therapeutic targets for anti-metastatic therapy in colorectal cancer2016

    • Author(s)
      Kawai T, Nagasaka T, Mori Y, Fuji T, Taniguchi F, Kimura K, Yasui K, Umeda Y, Tazawa H Goel A, Fujiwara T.
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      New Orleans,USA
    • Year and Date
      2016-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 切除可能局所進行直腸癌に対する術前化学療法および術前放射線化学療法の検討2016

    • Author(s)
      母里 淑子, 永坂 岳司, 岸本 浩行, 河合 毅, 工藤 泰崇, 樹下 真希, 近藤 喜太, 浅野 博昭, 佃 和憲, 藤原 俊義
    • Organizer
      第116回日本外科学会的学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸癌脳転移に対する集学的治療で長期生存を得た2例の検討2016

    • Author(s)
      吉川 公見子, 母里 淑子, 永坂 岳司, 岸本 浩行, 河合 毅, 藤原 俊義
    • Organizer
      第116回日本外科学会的学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer2016

    • Author(s)
      Mori Y,Shigeyasu K,Nagasaka T, Toyooka S, Fujiwara T
    • Organizer
      The 13th International Congress of Human Genetics
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-04-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Extended RAS/BRAF/MSI genetic変異、MGMT epigenetic変異を用いたStageIV大腸癌Precision Strategy2016

    • Author(s)
      母里淑子,永坂岳司,稲田涼,河合毅,岸本浩行,藤原俊義
    • Organizer
      第84回大腸癌研究会
    • Place of Presentation
      熊本
    • Year and Date
      2016-01-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 大腸癌卵巣転移に対する治療と予後2015

    • Author(s)
      母里淑子,永坂岳司,河合毅,竹原裕子,佃和憲,中谷紳,嶋村廣視,瀧上隆夫,富岡憲明,森谷行利,藤原俊義
    • Organizer
      第70回日本大腸肛門病学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 大腸癌治療戦略をどう組み立てるのか?臨床試験結果の使い方2014

    • Author(s)
      永坂岳司
    • Organizer
      Chugai Colorectal Cancer Seminar in Himeji
    • Place of Presentation
      姫路市
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical role of promoter hypermethylation in the MGMT gene during colorectal tumorigenesis2014

    • Author(s)
      Nagasaka T, Mori Y, Umeda Y, Takehara Y, Kawai T, Taniguchi F, Fuji T, Toshima T, Inada R, Kondo Y, OharaT, Kishimoto H, Nishizaki M, Kagawa S, Shirakawa Y, Yagi T, Fujiwara T
    • Organizer
      第25回日本消化器癌発生学会総会・第8回国際消化器癌発生会議
    • Place of Presentation
      福岡市
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] StageⅣ大腸がんの予後マーカーとしてのMGMTメチル化ステータスの有用性2014

    • Author(s)
      母里淑子, 永坂岳司, 稲田 涼, 戸嶋俊明, 竹原裕子, 中谷 紳, 竹原清人, 森川達也, 久保田暢人, 宇野 太, 滝上隆夫, 嶋村廣視, 森谷行利, 富岡憲明, 藤原俊義
    • Organizer
      第69回日本大腸肛門病学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌検診の短期・長期治療成績における有用性の検討2014

    • Author(s)
      戸嶋俊明, 稲田 涼, 永坂岳司, 母里淑子, 竹原裕子, 竹原清人, 佃 和憲, 藤原俊義
    • Organizer
      第69回日本大腸肛門病学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter as a prognostic biomarker for stage Ⅱ,Ⅲ and Ⅳcolorectal cancers2014

    • Author(s)
      Mori Y, Nagasaka T, Umeda Y, Shiwaku R. Inada R, Nishida N, Kishimoto H, Kagawa S, Tanioka H, Mishima H, Fujiwara T, Goel A
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid
    • Year and Date
      2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] MicroRNA-89 expression as a promising prognostic biomarker for advanced colorectal cancer2014

    • Author(s)
      Kubota N, Nagasaka T, Umeda Y, Mori Y, Kimura K, Taniguchi F, Tanioka H, Fujiwara T, Goel A
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid
    • Year and Date
      2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Cytokeratin 19, a novel prognostic biomarker for hepatocellular carcinoma, is regulated by DNA methylation2014

    • Author(s)
      Yokomichi N, Nagasaka T, Nishida N, Taniguchi F, Yoshida K, Tomokazu F, Kawai T, Takehara Y, Kimura K, Mori Y, Inada R, Umeda Y, Yagi T, Goel A, Fujiwara T
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid
    • Year and Date
      2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Extensive methylation of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) promoter could predict malignant formation in intraductal papillary mucinous neoplasms (IPMN)2014

    • Author(s)
      Yoshida K, Nagasaka T, Umeda Y, Yokomichi N, Mori Y, Takehara Y, Takehara K, Kawai T, Tomokazu F, Taniguchi F, Yagi T, Goel A, Fujiwara T
    • Organizer
      ESMO 2014 Congress
    • Place of Presentation
      Madrid
    • Year and Date
      2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 直腸癌に対する臨床試験に何が求められるか2014

    • Author(s)
      永坂岳司
    • Organizer
      第7回大腸がん分子標的薬治療研究会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 下部直腸癌に対する治療戦略~cetuximabは必要か~2014

    • Author(s)
      母里淑子
    • Organizer
      第7回大腸がん分子標的薬治療研究会
    • Place of Presentation
      岡山市
    • Year and Date
      2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 切除可能高リスク直腸癌に対する術前CapeOX+RTの安全性・有効性の検討2014

    • Author(s)
      母里淑子, 永坂岳司, 稲田 涼, 岸本浩行, 近藤喜太, 竹原裕子, 河合 毅, 藤 智和, 谷口文崇, 藤原俊義
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 臨床病期Ⅱ&Ⅲ直腸癌の遺伝子変異情報及び臨床病理学的所見と予後の検討2014

    • Author(s)
      永坂岳司, 岸本浩行, 母里淑子, 稲田 涼, 近藤喜太, 竹原裕子, 河合 毅, 藤 智和, 谷口文崇, 横道直佑, 久保田暢人, 吉田一博, 楳田祐三, 八木孝仁, 藤原俊義
    • Organizer
      第52回日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-08-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 局所進行直腸癌に対する術前放射線化学療法CapeOx RTの有効性・安全性の検討2014

    • Author(s)
      母里淑子, 永坂岳司, 稲田 涼, 岸本浩行, 近藤喜太, 藤 智和, 谷口文崇, 浅野博昭, 佃 和憲, 藤原俊義
    • Organizer
      第75回日本消化器外科学会総会
    • Place of Presentation
      郡山市
    • Year and Date
      2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌におけるprognostic factorとしてのmiRNAの検討2014

    • Author(s)
      久保田暢人, 永坂岳司, 吉田一博, 竹原裕子, 竹原清人, 稲田 涼, 河合 毅, 谷口文崇, 藤 智和, 藤原俊義
    • Organizer
      第75回日本消化器外科学会総会
    • Place of Presentation
      郡山市
    • Year and Date
      2014-07-17
    • Related Report
      2014 Research-status Report
  • [Presentation] KRAS/NRAS/BRAF/PIK3CA/MSI解析による多発大腸癌の遺伝子変異の不均一性の検討と臨床的意義2014

    • Author(s)
      稲田 涼, 永坂岳司, 母里淑子, 楳田祐三, 吉田一博, 久保田暢人, 竹原裕子, 竹原清人, 河合 毅, 藤原俊義
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌におけるprognostic factorとしてのmiRNA2014

    • Author(s)
      久保田暢人,永坂岳司,母里淑子,森川達也,吉田一博,横道直佑, 稲田 涼,竹原裕子,竹原清人, 河合 毅, 藤 智和, 楳田祐三,田澤 大, 藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 遺伝子変異情報を用いた直腸癌局所再発症例に対する治療戦略の検討2014

    • Author(s)
      永坂岳司, 母里淑子, 楳田祐三, 稲田 涼, 森川達也, 横道直佑, 久保田暢人, 吉田一博, 竹原裕子, 河合 毅, 藤 智和, 竹原清人, 杭瀬 崇, 谷口文崇, 近藤喜太, 岸本浩行, 浅野博昭, 佃 憲和, 貞森 裕, 八木孝仁, 藤原俊義
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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