Translational research on small intestinal elongation using tissue engineering technique

• Project/Area Number: 26462018
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kawasaki Medical School (2016); Yamaguchi University (2014-2015)
• Principal Investigator: UENO Tomio 川崎医科大学, 医学部, 教授 (70284255)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 小腸再生医療 / 小腸再生伸長術 / 小腸粘膜下組織 / 小腸再生 / 小腸伸長術 / Bianchi手術 / 短腸症候群

Outline of Final Research Achievements

We concluded that our present study provides the possibility of curative surgical treatment for patients with short bowel syndrome, in which small intestinal submucosa can potentially become more morphologically and physiologically supportive in small intestinal elongation using tissue engineering technique.

Research Products

• [Journal Article] 短腸症候群の再生治療 (2017)
  • Author(s): 上野富雄、中尾光宏、藤原由規、鶴田 淳、岡田敏正、岡 保夫、東田正陽、窪田寿子、渡邊裕策、浦岡未央、岡本由佑子、峯田修明、永野浩昭
  • Journal Title: 小児外科 Volume: 印刷中
• [Journal Article] Proposal of intestinal tissue engineering combined with Bianchi’s procedure. (2015)
  • Author(s): Mitsuhiro Nakao, Tomio Ueno, Atsunori Oga, Kuramitsu Yasuhiro, Nakatsu Hiroki, Masaaki Oka
  • Journal Title: Journal of Pediatric Surgery Volume: 50 Issue: 4 Pages: 573-580
  • DOI: 10.1016/j.jpedsurg.2014.11.035
  • Peer Reviewed / Open Access
• [Journal Article] Influence of mesenchymal stem cells on stomach tissue engineering using small intestinal submucosa (2015)
  • Author(s): Hiroki Nakatsu, Tomio Ueno, Atsunori Oga, Mitsuhiro Nakao, Taku Nishimura, Sei Kobayashi, Masaaki Oka
  • Journal Title: Journal of Tissue Engineering and Regenerative Medicine Volume: 9 Issue: 3 Pages: 296-304
  • DOI: 10.1002/term.1794
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 小腸再生伸長術―再生医療を応用した 短腸症候群患者に対する外科治療法 (2016)
  • Author(s): 上野富雄、藤本拓也、永野浩昭
  • Organizer: 第102回日本消化器病学会総会・ワークショップ
  • Place of Presentation: 京王プラザホテル （東京都新宿区）
  • Year and Date: 2016-04-22
• [Presentation] 小腸粘膜下組織（small intestinal submucosa: SIS）を用いた消化管再生医療 (2016)
  • Author(s): 上野富雄、藤本拓也、来嶋大樹、武田 茂、山本 滋、吉野茂文、硲 彰一、永野浩昭
  • Organizer: 第116回日本外科学会総会・シンポジウム
  • Place of Presentation: 大阪国際会議場 （大阪府大阪市）
  • Year and Date: 2016-04-15
• [Presentation] Gastrointestinal smooth muscle regeneration using absorbable extracellular matrix containing growth factors (2016)
  • Author(s): Tomio UENO, Hiroaki NAGANO
  • Organizer: 第93回日本生理学会・シンポジウム
  • Place of Presentation: 札幌コンベンションセンター (北海道札幌市）
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] 短腸症候群患者に対する再生医療を応用した外科治療法―大型動物を用いた前臨床研究― (2015)
  • Author(s): 上野富雄、藤本拓也、吉野茂文、硲 彰一、永野浩昭
  • Organizer: 第104回日本消化器病学会中国支部例会・シンポジウム
  • Place of Presentation: 岡山コンベンションセンター (岡山県岡山市）
  • Year and Date: 2015-12-05
• [Presentation] Intestinal elongation using small intestinal tissue engineering in combination with Bianchi's procedure (2015)
  • Author(s): Tomio UENO, Mitsuhiro NAKAO, Takuya FUJIMOTO, Takao TAMESA, Shigeru TAKEDA, Shigefumi YOSHINO, Shoichi HAZAMA, Hiroaki NAGANO
  • Organizer: United European Gastroenterology Week 2015
  • Place of Presentation: Fira Barcelona (Spain)
  • Year and Date: 2015-10-28
  • Int'l Joint Research
• [Presentation] Intestinal elongation using small intestinal tissue engineering in combination with Bianchi's procedure (2015)
  • Author(s): Tomio Ueno, Mitsuhiro Nakao, Takuya Fujimoto, Takao Tamesa, Shigeru Takeda, Shigefumi Yoshino, Shoichi Hazama, Hiroaki Nagano
  • Organizer: United European Gastroenterology Week (UEGW2015)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-10-24 – 2015-10-28