Visceral obesity impacts on adipokine expression and cancer recurrence in patients with colorectal cancer

• Project/Area Number: 26462020
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: MIYAMOTO Yuji 熊本大学, 医学部附属病院, 助教 (80551259)
• Co-Investigator(Kenkyū-buntansha): 坂本 快郎 熊本大学, 医学部附属病院, 講師 (00452897) ; 今村 裕 公益財団法人がん研究会, 有明病院 消化器外科, 医員 (70583045) ; 井田 智 公益財団法人がん研究会, 有明病院 消化器外科, 医員 (80583038)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 大腸癌 / 内臓肥満 / アディポカイン / レプチン / 炎症 / 手術 / 内臓脂肪 / アディポオカイン / 慢性炎症 / 肥満 / アディポサイトカイン

Outline of Final Research Achievements

We conducted a retrospective study of patients with stage I-III CRC who underwent curative resection to evaluate the correlation between long-term outcome and visceral fat area (VFA) measured by preoperative computed tomography, and to evaluate the impact of the expression of adipokines (leptin, IL-6, VEGF, and TNF-α) in visceral adipose specimens and serum samples on malignant potential.
Patients in the high VFA group had significantly higher recurrence rates than those in the normal VFA group for females (p<0.01) but not for males. Visceral leptin expression had a significant positive correlation with VFA in both genders. Serum levels of leptin and high-sensitivity C-reactive protein were significantly higher in patients with high visceral leptin expression than in those with low visceral leptin expression in females only. Serum leptin expression was independently associated with tumor vascular invasion (p=0.03).

Research Products

• [Journal Article] Recent Advances in Targeting the EGFR Signaling Pathway for the Treatment of Metastatic Colorectal Cancer. (2017)
  • Author(s): Miyamoto Y, Suyama K, Baba H.
  • Journal Title: Int J Mol Sci Volume: 18(4) Issue: 4 Pages: 752-752
  • DOI: 10.3390/ijms18040752
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of systemic inflammatory and nutritional scores in colorectal cancer patients who underwent potentially curative resection. (2017)
  • Author(s): Tokunaga R, Sakamoto Y, Nakagawa S, Izumi D, Kosumi K, Taki K, Higashi T, Miyata T, Miyamoto Y, Yoshida N, Baba H.
  • Journal Title: Int J Clin Oncol Volume: in press Issue: 4 Pages: 740-748
  • DOI: 10.1007/s10147-017-1102-5
  • Peer Reviewed
• [Journal Article] Omental flap after pelvic exenteration for pelvic cancer. (2016)
  • Author(s): Miyamoto Y, Akiyama T, Sakamoto Y, Tokunaga R, Ohuchi M, Shigaki H, Kurashige J, Iwatsuki M, Baba Y, Yoshida N, Baba H.
  • Journal Title: Surg Today Volume: 46(12) Issue: 12 Pages: 1471-1475
  • DOI: 10.1007/s00595-016-1348-y
  • Peer Reviewed
• [Journal Article] Prognostic Nutritional Index Predicts Severe Complications, Recurrence, and Poor Prognosis in Patients With Colorectal Cancer Undergoing Primary Tumor Resection. (2015)
  • Author(s): Tokunaga R, Sakamoto Y, Nakagawa S, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Baba H
  • Journal Title: Dis Colon Rectum Volume: 58(11) Issue: 11 Pages: 1048-57
  • DOI: 10.1097/dcr.0000000000000458
  • Peer Reviewed
• [Journal Article] Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in Patients with Unresectable Colorectal Cancer. (2015)
  • Author(s): Miyamoto Y, Baba Y, Sakamoto Y, Ohuchi M, Tokunaga R, Kurashige J, Hiyoshi Y, Iwagami S, Yoshida N, Watanabe M, Baba H.
  • Journal Title: PLoS One Volume: 10(6) Issue: 6 Pages: e0129742-e0129742
  • DOI: 10.1371/journal.pone.0129742
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Low Visceral Fat Content is Associated with Poor Prognosis in a Database of 507 Upper Gastrointestinal Cancers. (2015)
  • Author(s): Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ida S, Imamura Y, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Watanabe M, Baba H.
  • Journal Title: Ann Surg Oncol Volume: 22(12) Issue: 12 Pages: 3946-53
  • DOI: 10.1245/s10434-015-4432-4
  • Peer Reviewed
• [Journal Article] Sarcopenia is a Negative Prognostic Factor After Curative Resection of Colorectal Cancer. (2015)
  • Author(s): Miyamoto Y, Baba Y, Sakamoto Y, Ohuchi M, Tokunaga R, Kurashige J, Hiyoshi Y, Iwagami S, Yoshida N, Yoshida M, Watanabe M, Baba H.
  • Journal Title: Ann Surg Oncol Volume: 22(8) Issue: 8 Pages: 2663-8
  • DOI: 10.1245/s10434-014-4281-6
  • Peer Reviewed
• [Journal Article] Effects of obesity on the outcome of laparoscopic surgery for colorectal cancer (2014)
  • Author(s): Miyamoto Y, Ishii T, Tashiro J, Satoh T, Watanabe M, Baba H, Yamaguchi S
  • Journal Title: Surg Today Volume: 44(7) Issue: 7 Pages: 1293-9
  • DOI: 10.1007/s00595-013-0718-y
  • Peer Reviewed
• [Journal Article] Efficacy of S-1 in colorectal cancer (2014)
  • Author(s): Miyamoto Y, Sakamoto Y, Yoshida N, Baba H
  • Journal Title: Expert Opin Pharmacother Volume: 15 Issue: 12 Pages: 1761-70
  • DOI: 10.1517/14656566.2014.937706
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase-phosphoinositide 3-kinase-dependent anti-apoptotic signaling. (2014)
  • Author(s): Horiguchi H, Endo M, Miyamoto Y, Sakamoto Y, Odagiri H, Masuda T, Kadomatsu T, Tanoue H, Motokawa I, Terada K, Morioka MS, Manabe I, Baba H, Oike Y.
  • Journal Title: Cancer Science Volume: 105 Issue: 12 Pages: 1550-1559
  • DOI: 10.1111/cas.12554
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chemotherapy and targeted therapy for patients with initially unresectable colorectal liver metastases, focusing on conversion hepatectomy and long-term survival (2014)
  • Author(s): Beppu T, Miyamoto Y(equal contributor), Sakamoto Y, Imai K, Nitta H, Hayashi H, Chikamoto A, Watanabe M, Ishiko T, Baba H.
  • Journal Title: Ann Surg Oncol Volume: 21 Suppl 3 Issue: S3 Pages: 405-13
  • DOI: 10.1245/s10434-014-3577-x
  • Peer Reviewed
• [Presentation] Polymorphisms in adipokine-related genes to predict treatment outcomes in patients (pts) with metastatic colorectal cancer (mCRC) treated with bevacizumab-based chemotherapy. (2017)
  • Author(s): Yuji Miyamoto, Sebastian Stintzing, Wu Zhang, Shu Cao, Yan Ning, Satoshi Okazaki, Martin D. Berger, Mitsukuni Suenaga, Marta Schirripa, Shivani Soni, Satoshi Matsusaka, Dongyun Yang, Roel Gopez, Diana L. Hanna, Afsaneh Barzi, Hideo Baba, Volker Heinemann, Heinz-Josef Lenz.
  • Organizer: ASCO Gastrointestinal Cancers Symposium 2017
  • Place of Presentation: サンフランシスコ（アメリカ）
  • Year and Date: 2017-01-19
  • Int'l Joint Research
• [Presentation] 大腸癌における内臓脂肪とレプチンによる炎症の関連性 (2016)
  • Author(s): 大内 繭子、宮本 裕士、織田 枝里、内原 智幸、問端 輔、八木 泰祐、黒田 大介、江藤 二男、中村 健一、徳永 竜馬、美馬 浩介、木下 浩一、岩槻 政晃、馬場 祥史、坂本 快郎、吉田 直矢、馬場 秀夫.
  • Organizer: 第27回日本消化器癌発生学会総会
  • Place of Presentation: 城山観光ホテル（鹿児島県）
• [Presentation] 大腸癌における腹腔内脂肪量とアディポサイトカインの関連 (2015)
  • Author(s): 大内繭子、宮本裕士、清住雄希、中村健一、泉大輔、小澄敬祐、徳永竜馬、江藤弘二朗、杉原栄孝、原田和人、蔵重淳二、日吉幸晴、岩上志朗、馬場祥史、坂本快郎、吉田直矢、馬場秀夫
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Year and Date: 2015-04-18
• [Presentation] 食道扁平上皮癌における術前内臓脂肪と臨床病理学的因子の解析 (2014)
  • Author(s): 原田 和人
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03 – 2014-04-05