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Biological functions of a novel tumor suppressor gene candidate SVS-1 and its application to therapy for colorectal cancer

Research Project

Project/Area Number 26462022
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionFukushima Medical University

Principal Investigator

Kumamoto Kensuke  福島県立医科大学, 医学部, 准教授 (60457778)

Co-Investigator(Kenkyū-buntansha) 安藤 俊夫  福島県立医科大学, 医学部, 博士研究員 (20012693)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsSUSD2 / 大腸癌 / SUSV2 / Colorectal cancer / Susd2 / 癌抑制遺伝子 / 癌幹細胞 / SVS1 / SVS-1
Outline of Final Research Achievements

The SUSD2 gene is one of the novel tumor suppressor genes that we first discovered in the world. SUSD2 expression is decreased in various cancers including colon cancer compared to normal tissues. In this study, the biological function of SUSD2 was analyzed by in vitro experiments using colon cancer cells. When SUSD2 was highly expressed in cultured cells of colon cancer, all the ability of proliferation, migration and invasion were significantly reduced. Furthermore, we also confirmed a decrease in spheroid forming ability in three dimensional culture, which is one of the properties of cancer stem cells. SUSD2 inhibited the cell proliferation of cancer cells, inhibited the expression of a group of genes governing motor ability, and revealed that it suppresses various malignant traits of cancer.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] Susd2/SUSD2, a tumor suppressor gene and a seed for antitumor drug development2017

    • Author(s)
      Toshiwo Andoh, Kensuke Kumamoto, Tadashi Ohara
    • Organizer
      第76回 日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Candidate Tumor Suppressor Gene Susd2 inhibits growth of Cancer Cells by Preferentially Targeting Cancer Stem Cells (CSCs)2016

    • Author(s)
      安藤俊夫、竹之下誠一、隈元謙介
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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