| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
A concept of sessile serrated polyp has been proposed as a series of polyps with serration. Recent works led to recognize sessile serrated adenoma as precursor to many of the sporadic colorectal cancers with microsatellite instability (MSI). We focused on the methylation profile sharing between SSA and MSI cancer, which resulted in identification of 127 associated genes by an array-based methylation sensitive amplified fragment length polymorphism (MS-AFLP) method. AXIN is one of those genes, which cooperates with the tumor suppressor gene, APC to depredate beta-catenin. Its levels of methylation alterations increased along with progression from adenoma to carcinoma, and its expression levels negatively correlated with methylation. These findings suggested that AXIN was involved in the serrated pathway originated from sessile serrated polyp.
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