Mlignabt potential of serrated polyp estimated genomic profile
Project/Area Number |
26462023
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Jichi Medical University |
Principal Investigator |
Konishi Fumio 自治医科大学, 医学部, 名誉教授 (20142242)
|
Co-Investigator(Kenkyū-buntansha) |
鈴木 浩一 自治医科大学, 医学部, 准教授 (70332369)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 鋸歯状ポリープ / 鋸歯状腺腫 / マイクロサテライト不安定性 / 大腸癌 / メチル化プロファイル / sessile serrated adenoma / MSI大腸癌 / メチル化異常 / Axon guidance / AXIN / serrated pathway / AXIN遺伝子 / homeobox gene |
Outline of Final Research Achievements |
A concept of sessile serrated polyp has been proposed as a series of polyps with serration. Recent works led to recognize sessile serrated adenoma as precursor to many of the sporadic colorectal cancers with microsatellite instability (MSI). We focused on the methylation profile sharing between SSA and MSI cancer, which resulted in identification of 127 associated genes by an array-based methylation sensitive amplified fragment length polymorphism (MS-AFLP) method. AXIN is one of those genes, which cooperates with the tumor suppressor gene, APC to depredate beta-catenin. Its levels of methylation alterations increased along with progression from adenoma to carcinoma, and its expression levels negatively correlated with methylation. These findings suggested that AXIN was involved in the serrated pathway originated from sessile serrated polyp.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition2016
Author(s)
Muto Y, Suzuki K, Kato T, Tsujinaka S, Ichida K, Takayama Y, Fukui T, Kakizawa N, Watanabe F, Saito M, Futsuhara K, Noda H, Miyakura Y, Konishi F and Rikiyama
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Journal Title
Int J Oncol.
Volume: 49(3)
Issue: 3
Pages: 1057-1067
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability2014
Author(s)
Muto Y, Maeda T, Suzuki K, Kato T, Watanabe F, Kamiyama H, Saito M, Koizumi K, Miyaki Y, Konishi F, Alonso S, Perucho M, Rikiyama T
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Journal Title
BMC Cancer
Volume: 14
Issue: 1
Pages: 466-476
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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