| Project/Area Number |
26462036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
Kuboki Satoshi 千葉大学, 大学院医学研究院, 助教 (50571410)
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| Co-Investigator(Kenkyū-buntansha) |
宮崎 勝 国際医療福祉大学, 大学病院, 教授 (70166156)
清水 宏明 千葉大学, 大学院医学研究院, 准教授 (80272318)
酒井 望 千葉大学, 医学部附属病院, 助教 (70436385)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Ｐｉｎ１ / ＮＦ－ｋａｐｐａＢ / 肝胆膵領域癌 / ＳＴＡＴ３ / 肝細胞癌 / 膵癌 / 胆嚢癌 / Pin1 / 腫瘍細胞増殖 / 腫瘍細胞浸潤 / EMT / NF-kappaB |
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| Outline of Final Research Achievements |
Pin1-mediated NF-kappaB activation induced tumor cell proliferation and enhanced EMT, which promoted tumor progression in hepato-biliary-pancreatic cancer. Therefore, increased Pin1 expression in cancer cells was an independent prognostic factor after curative operation. Moreover, Pin1 inhibitors, PiB and Juglone, suppressed tumor cell proliferation in vitro and in animal model. Based on these results, we concluded that Pin1 was a potentially useful therapeutic target in patients with hepato-biliary-pancreatic cancer.
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