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Analyses of the relevance between microscopic cancer spread of colorectal liver metastases and perioperative chemotherapy

Research Project

Project/Area Number 26462038
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Hasegawa Kiyoshi  東京大学, 医学部附属病院, 准教授 (20292906)

Co-Investigator(Kenkyū-buntansha) 進藤 潤一  公益財団法人冲中記念成人病研究所, その他部局等, 研究員 (90701037)
大場 大  東京大学, 医学部附属病院, 助教 (10535529)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords大腸癌肝転移 / 周術期化学療法 / 分子標的治療薬 / 微小転移 / 形態学的腫瘍変化 / 病理学的微小転移 / 遺伝学的微小転移 / 形態学的奏功 / 分子標的薬 / RAS変異 / APC / 遺伝子変異
Outline of Final Research Achievements

Micrometastases exists around 20% of colorectal liver metastases (CLM), and preoperative chemotherapy for CLM reduces its frequency. Biologic agents, both anti-VEGF and anti-EGFR antibody, are associated with a decrease in the incidence of microscopic cancer spread beyond a width of 1 mm from the main lesion. Furthermore, in predicting the frequency and distribution of micrometastases around CLM the morphologic change in preoperative computed tomography is more favorable than the traditional tumor size-based criteria.
In patients with suboptimal morphologic response to preoperative chemotherapy for CLM, taking surgical margin more than 1mm prolongs surgical outcome. However, patients with optimal morphologic response show very good prognosis regardless of whether surgical margin is over 1mm or not, and the current study suggested the hepatic surgery with histological positive surgical margin can be acceptable, where necessary, in those patients with marginally resectable disease.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Clinical Impact of Preoperative Chemotherapy on Microscopic Cancer Spread Surrounding Colorectal Liver Metastases2017

    • Author(s)
      Nishioka Yujiro, Shindoh Junichi, Yoshioka Ryuji, Gonoi Wataru, Abe Hiroyuki, Okura Nnaoki, Yoshida Shuntaro, Sakamoto Yoshihiro, Hasegawa Kiyoshi, Fukayama Masashi, Kokudo Norihiro
    • Journal Title

      Annals of Surgical Oncology

      Volume: 印刷中 Issue: 8 Pages: 2326-2333

    • DOI

      10.1245/s10434-017-5845-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Survival benefit of repeat resection of successive recurrences after the initial hepatic resection for colorectal liver metastases.2016

    • Author(s)
      Oba M, Hasegawa K, Shindoh J, Yamashita S, Sakamoto Y, Makuuchi M, Kokudo N.
    • Journal Title

      Surgery

      Volume: 159 Issue: 2 Pages: 632-640

    • DOI

      10.1016/j.surg.2015.09.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiological Morphology of Colorectal Liver Metastases after Preoperative Chemotherapy Predicts Tumor Viability and Postoperative Outcomes.2015

    • Author(s)
      Nishioka Y, Shindoh J, Yoshioka R, Gonoi W, Abe H, Okura N, Yoshida S, Oba M, Hashimoto M, Watanabe G, Hasegawa K, Kokudo N.
    • Journal Title

      J Gastrointest Surg.

      Volume: 19 Issue: 9 Pages: 1653-1661

    • DOI

      10.1007/s11605-015-2836-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肝転移に対する外科治療の適応と術後補助化学療法; ここまできた専門的治療法―その進歩と最新の成績―2015

    • Author(s)
      長谷川潔、國土典宏
    • Journal Title

      Medical Practice

      Volume: 32 Pages: 1850-1856

    • Related Report
      2015 Research-status Report
  • [Journal Article] Discrepancy Between Recurrence-Free Survival and Overall Survival in Patients with Resectable Colorectal Liver Metastases: A Potential Surrogate Endpoint for Time to Surgical Failure.2014

    • Author(s)
      Oba M, Hasegawa K, Matsuyama Y, Shindoh J, Mise Y, Aoki T, Sakamoto Y, Sugawara Y, Makuuchi M, Kokudo N
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Issue: 6 Pages: 1817-24

    • DOI

      10.1245/s10434-014-3504-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] エビデンスにもとづく大腸癌肝転移に対する治療戦略の構築2015

    • Author(s)
      長谷川潔、大場大、國土典宏
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松
    • Year and Date
      2015-07-15 – 2015-07-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Establishment of therapeutic strategy for coloectal liver metastasis based on evidences.2015

    • Author(s)
      長谷川潔、大場大、國土典宏
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      アクトシティ浜松,オークラアクトシティホテル浜松,ホテルクラウンパレス浜松(静岡県・浜松市)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 腫瘍個数による大腸癌肝転移の手術適応の制限は適切か?2015

    • Author(s)
      長谷川潔、大場大、西岡裕次郎、吉岡龍二、進藤潤一、山本訓史、山下俊、赤松延久、有田淳一、金子順一、阪本良弘、國土典宏
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      ホテル グランパシフィック LE DAIBA (東京都・港区)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Is it proper to restrict surgical indication for colorectal liver metastases by tumor number?2015

    • Author(s)
      Kiyoshi Hasegawa, Masaru Oba, Yujiro Nishioka, Ryuji Yoshioka, Junichi Shindoh, Satoshi Yamamoto, Suguru Yamashita, Nobuhisa Akamatsu, Junichi Arita, Junichi Kaneko, Yoshihiro Sakamoto, Norihiro Kokudo
    • Organizer
      第27回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌肝転移に対し、肝切除は何個まで挑戦すべきか?2014

    • Author(s)
      長谷川潔、大場大、山下俊、西岡裕次郎、山本訓史、吉岡龍二、進藤潤一、石沢武彰、赤松延久、金子順一、青木琢、阪本良弘、菅原寧彦、國土典宏
    • Organizer
      第69回日本大腸肛門病学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 大腸癌肝転移再発に対する再切除を軸とした治療戦略2014

    • Author(s)
      長谷川潔、大場大、國土典宏
    • Organizer
      JDDW 2014
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Book] 肝転移の治療方針;第4章 治療図書『大腸腺腫・大腸癌 最新醫學別冊 診断と治療のABC 109 』2015

    • Author(s)
      長谷川潔、河口義邦、大道清彦、阪本良弘、國土典宏
    • Publisher
      最新医学社
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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