The impact of liver graft preservation using perfluorocarbon in donation after cardiac death liver transplantation.

• Project/Area Number: 26462041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto University
• Principal Investigator: Uemura Tadahiro 京都大学, 医学研究科, 非常勤講師 (90719949)
• Co-Investigator(Kenkyū-buntansha): 上本 伸二 京都大学, 医学研究科, 教授 (40252449) ; 藤本 康弘 京都大学, 医学研究科, 客員研究員 (80335281)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 心停止肝移植 / Perfluorocarbon / 心停止ドナー

Outline of Final Research Achievements

The outcome of donation after cardiac death (DCD) liver transplantation is worse compared with that of donation after brain death liver transplantation due to the long hypoxic period of donor warm ischemic time. Perfluorocarbon (PFC) is a compound with high oxygen carrying capacity. We investigated the impact of improved graft oxygenation provided by PFC addition on liver ischemia-reperfusion injury (IRI) and survival after DCD liver transplantation. Biochemical and histopathologic analysis showed that liver graft preservation with PFC attenuated liver IRI. Graft preservation with PFC improved postoperative survival. We are planning further investigations about the impact of PFC on ischemic cholangiopathy.