Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice

• Project/Area Number: 26462052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hokkaido University
• Principal Investigator: Hirano Satoshi 北海道大学, 医学研究科, 教授 (50322813)
• Co-Investigator(Kenkyū-buntansha): 土川 貴裕 北海道大学, 大学病院, 講師 (50507572) ; 中村 透 北海道大学, 医学研究科, 助教 (70645796)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: Ephrin receptor A4 / 分子標的治療 / 膵癌 / 膵癌新規分子標的治療薬 / 膵癌バイオマーカー

Outline of Final Research Achievements

Our study indicated that EphA4 expression was an independent prognostic factor in pancreatic cancer. Our study indicated that 2,5-dimethylpyrrolyl benzoic acid showed a cytostatic efficacy in pancreatic cancer expressing EphA4 in vitro and in vivo.

Research Products

• [Journal Article] Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice. (2015)
  • Author(s): Takano H, Nakamura T, Tsuchikawa T, Kushibiki T, Hontani K, Inoko K, Takahashi M, Sato S, Abe H, Takeuchi S, Sato N, Hiraoka K, Nishihara H, Shichinohe T, Hirano S.
  • Journal Title: Oncotarget Volume: 6 Issue: 38 Pages: 41063-76
  • DOI: 10.18632/oncotarget.5729
  • NAID: 120005697203
  • Peer Reviewed / Open Access