| Project/Area Number |
26462053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
青木 豪 東北大学, 大学病院, 助教 (10636955)
小玉 哲也 東北大学, 医工学研究科, 教授 (40271986)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 膵島移植 / 超音波検査 / 膵内分泌腫瘍 / 造影剤 / 微小気泡 / 膵神経内分泌腫瘍 |
|---|
| Outline of Final Research Achievements |
Islet transplantation is a cellular replacement therapy for severe diabetes mellitus. For the success of islet transplantation, it is important to engraft many transplanted islets. However, there are no examinations to evaluate the conditions of transplanted islets directly. Recently, many trials for evaluating the engraftment of islets using imaging examinations have been done. In this study, we tried to evaluate the engraftment and condition of transplanted islets using enhancement ultrasonography, and clarified that echogenicity of the transplanted mouse islets into diabetic mice was increased after injection of contrast agent, and correlation between the echogenicity and metabolic function of the diabetic mice. These findings revealed the possibility of the enhanced ultrasonography for evaluating the engraftment and condition of transplanted islets.
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