| Project/Area Number |
26462055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
若井 俊文 新潟大学, 医歯学系, 教授 (50372470)
坂田 純 新潟大学, 医歯学系, 講師 (70447605)
滝沢 一泰 新潟大学, 医歯学総合病院, 助教 (30706437)
高野 可赴 新潟大学, 医歯学系, 助教 (30606306)
小林 隆 新潟大学, 医歯学総合病院, 講師 (40464010)
小杉 伸一 新潟大学, 医歯学総合病院, 特任教授 (90401736)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 膵癌 / 5-ALA / 光線力学診断 / アミノレブリン酸 / PEPT-1 / PEPT-2 / 化学療法 |
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| Outline of Final Research Achievements |
Preoperative administration of 5-ALA induces fluorescence of specimens in pancreatic cancer. Fifteen pancreatic cancer patients were preoperatively given 5-ALA and fluorescence patterns of their specimen were observed. We categorized to three patterns (Category 0; no fluorescence, Category 1; fluorescence in spotted or small area, Category 2; fluorescence in whole area). The survival rate of the patients was significantly higher in Category 2 group than in category 0 and 1 group. The experiments using pancreatic cancer cell lines showed that 5-ALA induced fluorescence intensity is correlated to the response rate to gemcitabine.
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