Study for preoperative prediction of clinical relevant postoperative pancreatic fistula for safety early removal of drains
| Project/Area Number |
26462057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 大 金沢大学, 附属病院, 助教 (00645129)
牧野 勇 金沢大学, 医学系, 助教 (30543657)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膵液瘻 / 膵頭十二指腸切除術後 / 術前予測因子 / MDCT / MRI / 主膵管径 / 膵実質径 / 組織学的膵線維化率 / 造影MRI / 膵線維化面積比 / 膵脂肪化率 / CT造影パターン / MRIのT1値 / MRIのT2値 / 膵の線維化と脂肪変性 / 術前画像検査 / MDCTとMRI / 膵液瘻発生の術前予測 / 膵液瘻発生の予測 |
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| Outline of Final Research Achievements |
Reposition of drains or reoperation after early removal of drains in patients with pancrearic head resection is harmful and stressful for both patients and surgeons. The aim of this study is to clarify objective predictive parameters of clinical relevant postoperative pancreatic fistula (CR-POPF) preoperatively. We investigated high risk factors for CR-POPF in surgical factors, morphologic and imaging factors from CT or MRI and proportion of fibrous tissue and adipose tissue at cut margin of the pancreas. Histological fibrous ratio of pancreas, morphologic ratio of [width of the pancreas] / [diameter of main pancreatic duct] by CT axial imaging and CT value ratio of [pancreatic parenchyma] / [erector spinae muscles] in late phase are statistically significant factors. Latter two factors are preoperative predictive factors. Careful management of drain for high risk group makes early removal of drains safer.
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma.2017
Author(s)
Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y.
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Journal Title
Cancer Sci
Volume: 108
Issue: 11
Pages: 2122-2129
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inflammatory Features of Pancreatic Cancer Highlighted byMonocytes/Macrophages and CD4+ T cells with Clinical Impact.2015
Author(s)
Komura T, Sakai Y, Harada K, Kawaguchi K, Takabatake H, Kitagawa H, Wada T, Honda M, Ohta T, Nakanuma Y, Kaneko S.
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Journal Title
Cancer Sci.
Volume: 106(6)
Issue: 6
Pages: 672-86
DOI
Related Report
Peer Reviewed / Open Access
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