Reconstruction of pancreatic cancer microenvironment
| Project/Area Number |
26462059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kobe University |
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Principal Investigator |
SHIMIZU KAZUYA 神戸大学, 保健学研究科, 保健学研究員 (50335353)
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| Co-Investigator(Kenkyū-buntansha) |
堀 裕一 神戸大学, 保健学研究科, 教授 (80248004)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵臓がん / がん幹細胞 / 胚性幹細胞 / 膵臓外科学 / 微小環境 / 膵臓癌 / 癌微小環境 / iPS / がん微小環境 |
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| Outline of Final Research Achievements |
Pancreatic cancer shows an aggressive phenotype with a dismal prognosis despite of multimodal therapy. Notably, neural invasion is a life-threatening problem. In this study, we aimed to reconstruct microenvironment around pancreatic cancer cells. First, we developed novel mouse pancreatic cancer stem cells by introducing mutated KRAS, mutated p53, and CDK4 oncogenes common in human pancreatic cancer to mouse pancreatic stem/progenitor cells. Then, we established co-culture system between multipotent stem cells and pancreatic cancer cells. We found that both mouse embryonic stem cells and human induced pluripotent stem cells could differentiate into neural cells such as neuron or glia cells in vitro and in vivo. These results indicate that this system might be potent tool to develop novel treatment strategy for pancreatic cancer.
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Report
(4 results)
Research Products
(17 results)
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[Book] 南江堂2016
Author(s)
下瀬川徹編 堀裕一
Total Pages
515
Publisher
新膵臓病学
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