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Nerve growth factor expression and perineural invasion in bile carcinoma

Research Project

Project/Area Number 26462061
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionHiroshima University

Principal Investigator

Uemura Kenichiro  広島大学, 医歯薬保健学研究院(医), 講師 (60379873)

Co-Investigator(Kenkyū-buntansha) 村上 義昭  広島大学, 医歯薬保健学研究院(医), 准教授 (10263683)
橋本 泰司  広島大学, 病院(医), 病院助教 (50423380)
Co-Investigator(Renkei-kenkyūsha) HIYAMA EISO  広島大学, 自然科学研究支援開発センター, 教授 (00218744)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胆管癌 / 神経周囲浸潤 / Nerve Growth Factor / NGF / neurotrophic factor / 発生モデル
Outline of Final Research Achievements

To investigate the impact of intratumoral nerve growth factor expression in resected extrahepatic cholangiocarcinoma on survival.Intratumoral nerve growth factor expression was investigated immunohistochemically in 112 patients with resected extrahepatic cholangiocarcinoma.High and low nerve growth factor expression was observed in 62 (55%) and 50 (45%) patients, respectively. For all 112 patients, no significant correlation was found between nerve growth factor expression and presence of perineural invasion (P = 0.942). Moreover, nerve growth factor expression was not associated with recurrence-free survival (P = 0.861) and overall survival (P = 0.973).
Intratumoral nerve growth factor expression is not associated with perineural invasion or recurrence-free and overall survival in patients with resected extrahepatic cholangiocarcinoma.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Nerve Growth Factor Expression Is Not Associated with Perineural Invasion in Extrahepatic Cholangiocarcinoma2015

    • Author(s)
      Urabe K, Murakami Y, Kondo N, Uemura K, Hashimoto Y, Nakagawa N, Sasaki H, Hiyama E, Takahashi S, Sueda T.
    • Journal Title

      Digestive Diseases and Sciences

      Volume: 61 Issue: 3 Pages: 774-784

    • DOI

      10.1007/s10620-015-3953-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 肝外胆管癌における神経周囲浸潤の程度評価が予後に及ぼす影響2016

    • Author(s)
      浦部和秀、村上義昭、上村健一郎、橋本泰司、近藤成、中川直哉、末田泰二郎
    • Organizer
      日本外科学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 切除可能肝外胆管癌におけるNerve Growth Factor発現と神経周囲浸潤との関連性の検討2015

    • Author(s)
      浦部和秀、村上義昭、上村健一郎、他
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2015-07-15 – 2015-07-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Impact of intratumoral nerve growth factor expression on perineural invasion and prognosis2015

    • Author(s)
      K Urabe、Y.Murakami, K Uemura, et al.
    • Organizer
      Digestive Disease Week
    • Place of Presentation
      アメリカ・ワシントンDC
    • Year and Date
      2015-05-16 – 2015-05-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 胆管癌におけるNerve Growth Factor発現と神経周囲浸潤との関連性についての検討2015

    • Author(s)
      浦部和秀、村上義昭、上村健一郎、他
    • Organizer
      日本外科学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-04-16 – 2015-04-18
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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