Nerve growth factor expression and perineural invasion in bile carcinoma

• Project/Area Number: 26462061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: Uemura Kenichiro 広島大学, 医歯薬保健学研究院(医), 講師 (60379873)
• Co-Investigator(Kenkyū-buntansha): 村上 義昭 広島大学, 医歯薬保健学研究院(医), 准教授 (10263683) ; 橋本 泰司 広島大学, 病院(医), 病院助教 (50423380)
• Co-Investigator(Renkei-kenkyūsha): HIYAMA EISO 広島大学, 自然科学研究支援開発センター, 教授 (00218744)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胆管癌 / 神経周囲浸潤 / Nerve Growth Factor / NGF / neurotrophic factor / 発生モデル

Outline of Final Research Achievements

To investigate the impact of intratumoral nerve growth factor expression in resected extrahepatic cholangiocarcinoma on survival.Intratumoral nerve growth factor expression was investigated immunohistochemically in 112 patients with resected extrahepatic cholangiocarcinoma.High and low nerve growth factor expression was observed in 62 (55%) and 50 (45%) patients, respectively. For all 112 patients, no significant correlation was found between nerve growth factor expression and presence of perineural invasion (P = 0.942). Moreover, nerve growth factor expression was not associated with recurrence-free survival (P = 0.861) and overall survival (P = 0.973).
Intratumoral nerve growth factor expression is not associated with perineural invasion or recurrence-free and overall survival in patients with resected extrahepatic cholangiocarcinoma.

Research Products

• [Journal Article] Nerve Growth Factor Expression Is Not Associated with Perineural Invasion in Extrahepatic Cholangiocarcinoma (2015)
  • Author(s): Urabe K, Murakami Y, Kondo N, Uemura K, Hashimoto Y, Nakagawa N, Sasaki H, Hiyama E, Takahashi S, Sueda T.
  • Journal Title: Digestive Diseases and Sciences Volume: 61 Issue: 3 Pages: 774-784
  • DOI: 10.1007/s10620-015-3953-9
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 肝外胆管癌における神経周囲浸潤の程度評価が予後に及ぼす影響 (2016)
  • Author(s): 浦部和秀、村上義昭、上村健一郎、橋本泰司、近藤成、中川直哉、末田泰二郎
  • Organizer: 日本外科学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2016-04-16
• [Presentation] 切除可能肝外胆管癌におけるNerve Growth Factor発現と神経周囲浸潤との関連性の検討 (2015)
  • Author(s): 浦部和秀、村上義昭、上村健一郎、他
  • Organizer: 日本消化器外科学会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2015-07-15 – 2015-07-16
• [Presentation] Impact of intratumoral nerve growth factor expression on perineural invasion and prognosis (2015)
  • Author(s): K Urabe、Y.Murakami, K Uemura, et al.
  • Organizer: Digestive Disease Week
  • Place of Presentation: アメリカ・ワシントンDC
  • Year and Date: 2015-05-16 – 2015-05-18
• [Presentation] 胆管癌におけるNerve Growth Factor発現と神経周囲浸潤との関連性についての検討 (2015)
  • Author(s): 浦部和秀、村上義昭、上村健一郎、他
  • Organizer: 日本外科学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-04-16 – 2015-04-18