| Project/Area Number |
26462063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
FUJITA Hayato 九州大学, 医学研究院, 助教 (40611281)
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| Co-Investigator(Kenkyū-buntansha) |
前山 良 九州大学, 医学研究院, 共同研究員 (10611668)
田中 雅夫 九州大学, 医学研究院, 教授 (30163570)
江上 拓哉 九州大学, 医学研究院, 共同研究員 (40507787)
真鍋 達也 九州大学, 大学病院, 講師 (60546464)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 膵癌 / 肝転移 / 間質リモデリング / 線維芽細胞 |
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| Outline of Final Research Achievements |
The aim of this study is to develop a new therapeutic strategy targeting the specific cell population and its molecular mechanism.
Microarray analysis revealed the lower miR-5100 expression in the highly metastatic pancreatic cancer cell, and we found the fact that the expression of PODXL, a target gene of miR-5100, correlates with the patients’ survival and the frequency of liver metastasis. PODXL knock down in the pancreatic cancer cell decreased its aggressive phenotype, suggesting that PODXL is a potential therapeutic target to inhibit liver metastasis.
Further, observation of the liver and lung metastasis mouse model revealed the fact that liver metastases contains significantly more α-SMA positive stromal cells than lung metastases.
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